Mechanisms of protection against simian immunodeficiency virus infection

被引：26

作者：

Johnson, RP

机构：

[1] Harvard Univ, New England Reg Primate Res Ctr, Sch Med, Div Immunol, Southborough, MA 01772 USA

[2] Massachusetts Gen Hosp, Partners AIDS Res Ctr, Charlestown, MA 02129 USA

[3] Massachusetts Gen Hosp, Infect Dis Unit, Charlestown, MA 02129 USA

来源：

VACCINE | 2002年 / 20卷 / 15期

关键词：

cytotoxic T lymphocyte; simian immunodeficiency viruses; HIV; attenuated vaccines;

D O I：

10.1016/S0264-410X(02)00083-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

One of the obstacles to the development of an effective AIDS vaccine has been the limited information on the mechanisms of protective immunity to HIV. In macaques, immunization with attenuated simian immunodeficiency viruses (SIV) has proved to be one of the most effective strategies to induce protection against infection or disease with pathogenic lentiviruses. Infection with attenuated SIV strains induces a broad range of SIV-specific immune responses, including relatively potent cytotoxic T lymphocyte (CTL) and antibody responses. Several studies of macaques vaccinated with attenuated SIV have demonstrated correlations between CTL responses or antibody responses and protection but more detailed studies are needed to document the relative importance of these responses in protective immunity. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1985 / 1987

页数：3

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