Synthesis and stereochemistry of the antitumor diterpenoid (+)-zerumin B

被引：51

作者：

Boukouvalas, John ^{[1
]}

Wang, Jian-Xin ^{[1
]}

Marion, Olivier ^{[1
]}

Ndzi, Bruno ^{[1
]}

机构：

[1] Univ Laval, Dept Chim, Quebec City, PQ G1K 7P4, Canada

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 17期

关键词：

D O I：

10.1021/jo0610154

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from commercially available (+)-sclareolide, the first synthesis of zerumin B was achieved by a concise, highly efficient pathway featuring stereoselective addition of a new silyloxyfuryltitanium reagent to an aldehyde intermediate and silyloxyfuran oxyfunctionalization as key steps. The synthesis established the relative and absolute configuration of zerumin B along with its identity with a purportedly new diterpenoid isolated from the plant Renealmia alpinia.

引用

页码：6670 / 6673

页数：4

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