The transcriptional coactivators p300 and CBP are histone acetyltransferases

被引：2411
|
作者：
Ogryzko, VV
Schiltz, RL
Russanova, V
Howard, BH
Nakatani, Y
机构：
[1] Lab. of Molecular Growth Regulation, Natl. Inst. of Child Hlth./Hum. D., National Institutes of Health, Bethesda
来源：
CELL | 1996年 / 87卷 / 05期
关键词：
D O I：
10.1016/S0092-8674(00)82001-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
p300/CBP is a transcriptional adaptor that integrates signals from many sequence-specific activators via direct interactions. Various cellular and viral factors target p300/CBP to modulate transcription and/or cell cycle progression. One such factor, the cellular p300/CBP associated factor (PCAF), possesses intrinsic histone acetyltransferase activity. Here, we demonstrate that p300/CBP is not only a transcriptional adaptor but also a histone acetyltransferase. p300/CBP represents a novel class of acetyltransferases in that it does not have the conserved motif found among various other acetyltransferases. p300/CBP acetylates all four core histones in nucleosomes. These observations suggest that p300/CBP acetylates nucleosomes in concert with PCAF.
引用
收藏
页码：953 / 959
页数：7
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