Iridium-Catalyzed Reactions of Trifluoromethylated Compounds with Alkenes: A Csp3-H Bond Activation α to the Trifluoromethyl Group

被引：39

作者：

Guo, Yong ^{[1
]}

Zhao, Xiaming ^{[1
]}

Zhang, Dazhi ^{[1
]}

Murahashi, Shun-Ichi ^{[1
]}

机构：

[1] Okayama Univ Sci, Dept Chem, Okayama 7000005, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 11期

关键词：

alkenes; C H activation; fluorides; iridium; ruthenium; C-F BONDS; CROSS-COUPLING REACTION; GRIGNARD-REAGENTS; NUCLEOPHILIC TRIFLUOROMETHYLATION; PERFLUOROALKYL-COMPLEXES; FLUOROALKYL-COMPLEXES; ELECTRONIC-PROPERTIES; HYDRIDE COMPLEXES; ARYL FLUORIDES; LEWIS-ACID;

D O I：

10.1002/anie.200805852

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Catalytic convenience: The use of iridium or ruthenium catalysts for Csp3-H bond activation has led to the addition reaction of trifluoromethylated compounds to alkenes (see scheme). This atom-economical reaction occurs under neutral reaction conditions and without the formation of undesired defluorinated byproducts, even at high temperature. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2047 / 2049

页数：3

共 54 条

[1] Efficient aryl-(hetero)aryl coupling by activation of C-Cl and C-F bonds using nickel complexes of air-stable phosphine oxides [J].