Equine adipose-derived stem cell (ASC) expresses BAFF and its receptors, which may be associated with the differentiation process of ASC towards adipocyte

被引：5

作者：

Wu, Haitao ^{[1
,2
,3
,4
]}

Han, Dongju ^{[1
,3
,4
]}

Jiang, Zhengan ^{[1
,3
,4
]}

Zhao, Dongwei ^{[1
,3
,4
]}

Liu, Meng ^{[1
,3
,4
]}

Xu, Xingzhou ^{[1
,3
,4
]}

Liu, Xia ^{[1
,3
,4
]}

Yang, Lin ^{[1
,3
,4
]}

Ji, Xuemei ^{[1
,3
,4
]}

Wang, Mingyan ^{[2
]}

Zhang, Shuangquan ^{[1
,3
,4
]}

机构：

[1] Nanjing Normal Univ, Life Sci Coll, Jiangsu Key Lab Mol & Med Biotechnol, Nanjing 210023, Jiangsu, Peoples R China

[2] Nanjing Univ Chinese Med, Basic Med Coll, Nanjing 210023, Jiangsu, Peoples R China

[3] Nanjing Normal Univ, Life Sci Coll, Jiangsu Key Lab Aquat Crustacean Dis, Nanjing 210023, Jiangsu, Peoples R China

[4] Nanjing Normal Univ, Life Sci Coll, Jiangsu Key Lab Supramol Med Mat & Applicat, Nanjing 210023, Jiangsu, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2014年 / 18卷 / 02期

关键词：

Equine; Horse; BAFF; Adipose-derived stem cell; Adipogenic differentiation; ACTIVATING FACTOR; APRIL; TISSUE; PROLIFERATION; SURVIVAL; BETA;

D O I：

10.1016/j.intimp.2013.12.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

B cell activating factor (BAFF) and its receptors were regarded as elements of the immune system, regulating the fate of B cell. In recent years, these molecules were identified in a number of normal and pathological tissues, expanding their potential functions beyond the immune system. In this study, on the basis of molecular clone and prokaryotic expression of equine BAFF, we reported that equine adipose-derived stem cell (ASC) expressed BAFF and its receptors, which exhibited the increased expression during ASC adipogenic differentiation in vitro. Moreover, with the addition of recombinant protein His(6)-sBAFF, an increased differentiation of equine ASC towards adipocyte was detected. These results suggested that BAFF and its receptors might be associated with the differentiation process of ASC towards adipocyte in horse. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：365 / 372

页数：8

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