The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly

被引：889

作者：

Ahmad, K ^{[1
]}

Henikoff, S ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

来源：

MOLECULAR CELL | 2002年 / 9卷 / 06期

关键词：

D O I：

10.1016/S1097-2765(02)00542-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two very similar H3 histones-differing at only four amino acid positions-are produced in Drosophila cells. Here we describe a mechanism of chromatin regulation whereby the variant H3.3 is deposited at particular loci, including active rDNA arrays. While the major H3 is incorporated strictly during DNA replication, amino acid changes toward H3.3 allow replication-independent (RI) deposition. In contrast to replication-coupled (RC) deposition, RI deposition does not require the N-terminal tall. H3.3 is the exclusive substrate for RI deposition, and its counterpart is the only substrate retained in yeast. RI substitution of H3.3 provides a mechanism for the immediate activation of genes that are silenced by histone modification. Inheritance of newly deposited nucleosomes may then mark sites as active loci.

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页码：1191 / 1200

页数：10

相关论文

共 64 条

[1] Centromeres are specialized replication domains in heterochromatin [J].

Ahmad, K ;

Henikoff, S .

JOURNAL OF CELL BIOLOGY, 2001, 153 (01) :101-109

[2] The localization of histone H3.3 in germ line chromatin of Drosophila males as established with a histone H3.3-specific antiserum [J].

Akhmanova, A ;

Miedema, K ;

Wang, Y ;

vanBruggen, M ;

Berden, JHM ;

Moudrianakis, EN ;

Hennig, W .

CHROMOSOMA, 1997, 106 (06) :335-347

[3] STRUCTURE AND EXPRESSION OF HISTONE H3.3 GENES IN DROSOPHILA-MELANOGASTER AND DROSOPHILA-HYDEI [J].

AKHMANOVA, AS ;

BINDELS, PCT ;

XU, J ;

MIEDEMA, K ;

KREMER, H ;

HENNIG, W .

GENOME, 1995, 38 (03) :586-600

[4] HISTONE REARRANGEMENTS ACCOMPANY NUCLEAR DIFFERENTIATION AND DEDIFFERENTIATION IN TETRAHYMENA [J].

ALLIS, CD ;

WIGGINS, JC .

DEVELOPMENTAL BIOLOGY, 1984, 101 (02) :282-294

[5] Histone modification governs the cell cycle regulation of a replication-independent chromatin assembly pathway in Saccharomyces cerevisiae [J].

Altheim, BA ;

Schultz, MC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (04) :1345-1350

[6]

Arenhovel H., 1991, Few-Body Systems Supplementum, P1, DOI 10.1007/978-3-7091-6701-4_1

[7] THE HISTONE FOLD - A UBIQUITOUS ARCHITECTURAL MOTIF UTILIZED IN DNA COMPACTION AND PROTEIN DIMERIZATION [J].

ARENTS, G ;

MOUDRIANAKIS, EN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (24) :11170-11174

[8] Chromatin-bound PCNA complex formation triggered by DNA damage occurs independent of the ATM gene product in human cells [J].

Balajee, AS ;

Geard, CR .

NUCLEIC ACIDS RESEARCH, 2001, 29 (06) :1341-1351

[9] Histone Sequence Database: new histone fold family members [J].

Baxevanis, AD ;

Landsman, D .

NUCLEIC ACIDS RESEARCH, 1998, 26 (01) :372-375

[10] THE CODING SEQUENCES OF MOUSE H2A AND H3 HISTONE GENES CONTAINS A CONSERVED 7-NUCLEOTIDE ELEMENT THAT INTERACTS WITH NUCLEAR FACTORS AND IS NECESSARY FOR NORMAL EXPRESSION [J].

BOWMAN, TL ;

HURT, MM .

NUCLEIC ACIDS RESEARCH, 1995, 23 (16) :3083-3092

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