Insights in Nanoparticle-Bacterium Interactions: New Frontiers to Bypass Bacterial Resistance to Antibiotics

被引:24
作者
Diab, Roudayna [1 ,2 ]
Khameneh, Bahman [3 ]
Joubert, Olivier [4 ]
Duval, Raphael [1 ,2 ,5 ]
机构
[1] CNRS, SRSMC, UMR 7565, F-54506 Vandoeuvre Les Nancy, France
[2] Univ Lorraine, SRSMC, UMR 7565, F-54001 Nancy, France
[3] Mashhad Univ Med Sci, Students Res Comm, Dept Food & Drug Control, Mashhad, Iran
[4] Univ Lorraine, CITHEFOR, EA 3452, F-54001 Nancy, France
[5] ABC Platform, F-54001 Nancy, France
关键词
Antibiotic; controlled-release; liposome; nanoparticle; resistance; targeting; PSEUDOMONAS-AERUGINOSA; STAPHYLOCOCCUS-AUREUS; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; HELICOBACTER-PYLORI; OXIDATIVE STRESS; PHASE-TRANSITIONS; VIRULENCE FACTORS; CELL-MEMBRANE; IN-VITRO;
D O I
10.2174/138161282128150922175445
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Nanotechnology has been revealed as a fundamental approach for antibiotics delivery. In this paper, recent findings demonstrating the superiority of nanocarried-antibiotics over "naked" ones and the ways by which nanoparticles can help to overwhelm bacterial drug resistance are reviewed. The second part of this paper sheds light on nanoparticle-bacterium interaction patterns. Finally, key factors affecting the effectiveness of nanoparticles interactions with bacteria are discussed.
引用
收藏
页码:4095 / 4105
页数:11
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