A sodium alginate-based sustained-release IPN hydrogel and its applications

被引：108

作者：

Zou, Zuhao ^{[1
]}

Zhang, Bijun ^{[1
]}

Nie, Xiaoqin ^{[1
]}

Cheng, Yu ^{[1
]}

Hu, Zhang ^{[1
]}

Liao, Mingneng ^{[1
]}

Li, Sidong ^{[1
]}

机构：

[1] Guangdong Ocean Univ, Fac Chem & Environm Sci, Zhanjiang 524088, Peoples R China

来源：

RSC ADVANCES | 2020年 / 10卷 / 65期

关键词：

POLYMER NETWORK HYDROGELS; DRUG-DELIVERY; POLY(VINYL ALCOHOL); PROTEIN DELIVERY; CELL DELIVERY; IN-VITRO; PH; MICROSPHERES; BEHAVIOR; GELATIN;

D O I：

10.1039/d0ra04316h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Interpenetrating polymer network (IPN) hydrogels are crosslinked by two or more polymer networks, providing free volume space in the three-dimensional network structure, and providing conditions for the sustained and controlled release of drugs. The IPN hydrogels based on the natural polymer sodium alginate can form a stable porous network structure. Due to its excellent biocompatibility, the loaded drug can be sustained to the maximum extent without affecting its pharmacological effect. Sodium alginate-based IPN hydrogels have broad application prospects in the field of sustained and controlled drug release. This paper begins with an overview of the formation of alginate-based IPN hydrogels; summarizes the types of alginate-based IPN hydrogels; and discusses the pharmaceutical applications of alginate-based IPN hydrogels. We aim to give an overview of the research on IPN hydrogels based on sodium alginate in sustained and controlled drug release systems.

引用

页码：39722 / 39730

页数：9

共 97 条

[1] Preparation and characterization of sodium alginate/polyvinyl alcohol hydrogel containing drug -loaded chitosan nanoparticles as a drug delivery system [J].

Afshar, M. ;

Dini, G. ;

Vaezifar, S. ;

Mehdikhani, M. ;

Movahedi, B. .

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2020, 56

[2] Stimuli responsive polymers for biomedical applications [J].

Alarcón, CDH ;

Pennadam, S ;

Alexander, C .

CHEMICAL SOCIETY REVIEWS, 2005, 34 (03) :276-285

[3]

Alka L., 2014, J DRUG DELIVERY, V2014, P1

[4] Examination of In vitro and In vivo biocompatibility of alginate-hyaluronic acid microbeads As a promising method in cell delivery for kidney regeneration [J].

Amirian, Jhaleh ;

Van, Tran Thi Tuong ;

Bae, Sang-Ho ;

Jung, Hae-Il ;

Choi, Hwan-Jun ;

Cho, Hyun-Deuk ;

Lee, Byong-Taek .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017, 105 :143-153

[5] Alginate hydrogels as biomaterials [J].

Augst, Alexander D. ;

Kong, Hyun Joon ;

Mooney, David J. .

MACROMOLECULAR BIOSCIENCE, 2006, 6 (08) :623-633

[6] Green synthesis and swelling behavior of Ag-nanocomposite semi-IPN hydrogels and their drug delivery using Dolichos biflorus Linn [J].

Basu, Shibani ;

Samanta, Himadri Sekhar ;

Ganguly, Jhuma .

SOFT MATERIALS, 2018, 16 (01) :7-19

[7] PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release [J].

Bhattarai, N ;

Ramay, HR ;

Gunn, J ;

Matsen, FA ;

Zhang, MQ .

JOURNAL OF CONTROLLED RELEASE, 2005, 103 (03) :609-624

[8] Sodium alginate and gelatin hydrogels: Viscosity effect on hydrophobic drug release [J].

Bhutani, Utkarsh ;

Laha, Anindita ;

Mitra, Kishalay ;

Majumdar, Saptarshi .

MATERIALS LETTERS, 2016, 164 :76-79

[9] Injectable alginate hydrogels for cell delivery in tissue engineering [J].

Bidarra, Silvia J. ;

Barrias, Cristina C. ;

Granja, Pedro L. .

ACTA BIOMATERIALIA, 2014, 10 (04) :1646-1662

[10] Glucose oxidase release from calcium alginate gel capsules [J].

Blandino, A ;

Macías, M ;

Cantero, D .

ENZYME AND MICROBIAL TECHNOLOGY, 2000, 27 (3-5) :319-324

← 1 2 3 4 5 6 7 8 9 10 →