Improved Synthesis Technology of (S)-benzyl-2-(benzyloxycarbonylamino)-4-oxobutanoate

被引：0

作者：

An, Lian-Ying ^{[1
]}

Zhang, Zhen-Guo ^{[1
]}

Zhao, Xian-Yin ^{[1
]}

Lei, Ning ^{[1
]}

Pei, Ling-Fang ^{[1
]}

机构：

[1] Chengdu Univ Technol, Coll Mat & Chem & Chem Engn, Chengdu, Sichuang, Peoples R China

来源：

2011 AASRI CONFERENCE ON INFORMATION TECHNOLOGY AND ECONOMIC DEVELOPMENT (AASRI-ITED 2011), VOL 3 | 2011年

关键词：

(S)-benzyl-2-(benzyloxycarbonylamino)-4-oxobutanoate; L-methionine; Synthesis; PCC oxidation; TEMPO-mediated oxidation; OXIDATION;

D O I：

暂无

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

(S)-benzyl-2-(benzyloxycarbonylamino)-4-oxobutanoate, a key intermediate for the preparation of chiral bicyclic amidines and guanidines, has been synthesized stereoselectively using L-methionine as starting materials through six steps, such as hydrolysis reaction, halogenation reaction, collins reagent oxidation and so on. The structure of the compound was identified by H-NIVIR, IR, and MS analysis. The Purity and the ee value of the compounds were 99.3% and 99.5% respectively.The total yield was 85.07%.

引用

页码：63 / 66

页数：4

共 19 条

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