TICT based fluorescent probe with excellent photostability for real-time and long-term imaging of lipid droplets

被引：14

作者：

Li, Yunxia ^{[1
,2
,3
]}

Zhang, Minjie ^{[1
,2
,3
]}

Chen, Xiaohui ^{[1
,2
,3
]}

Liang, Jianshu ^{[4
]}

Chen, Dongcheng ^{[4
]}

Gao, Meng ^{[1
,2
,3
]}

Ren, Li ^{[1
,2
,3
]}

机构：

[1] South China Univ Technol, Sch Mat Sci & Engn, Guangzhou 510640, Guangdong, Peoples R China

[2] South China Univ Technol, Natl Engn Res Ctr Tissue Restorat & Reconstruct, Guangzhou 5100, Guangdong, Peoples R China

[3] South China Univ Technol, Key Lab Biomed Engn Guangdong Prov, Guangzhou 51006, Guangdong, Peoples R China

[4] South China Univ Technol, Inst Polymer Optoelect Mat & Devices, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Guangdong, Peoples R China

来源：

TETRAHEDRON LETTERS | 2019年 / 60卷 / 29期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Lipid droplets; Twisted intramolecular charge transfer; Long-term imaging; Excellent photostability; INTRAMOLECULAR CHARGE-TRANSFER; CELLS;

D O I：

10.1016/j.tetlet.2019.06.007

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lipid droplets (LDs) are dynamic organelles and involve in various physiological processes by regulation of the storage and metabolism of lipid molecules. The real-time and long-term imaging of LDs' distribution and movement is critical for investigation of their biological functions. However, current LDs-targeted fluorescent probes suffer from low photostability and high background noise. To tackle these challenges, we herein reported that the red-emissive fluorescent probe DCQTB with twisted intramolecular charge transfer (TICT) characteristics can be used for wash-free imaging of LDs with advantages of fast cell penetration ability, high specificity, excellent photostability, and low phototoxicity. This LDs-specific fluorescent probe is thus promising for investigation of the biological functions of LDs. (C) 2019 Published by Elsevier Ltd.

引用

页码：1880 / 1884

页数：5

共 29 条

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