Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease

被引：54

作者：

Chiesa, Patrizia A. ^{[1
,2
,3
]}

Cavedo, Enrica ^{[1
,2
,3
]}

Vergallo, Andrea ^{[1
,2
,3
]}

Lista, Simone ^{[1
,2
,3
]}

Potier, Marie-Claude ^{[1
,2
,3
]}

Habert, Marie-Odile ^{[4
]}

Dubois, Bruno ^{[5
,6
,7
]}

de Schotten, Michel Thiebaut ^{[1
,2
,3
]}

Hampel, Harald ^{[2
,8
,9
,10
]}

Bakardjian, Hovagim

Benali, Habib

Bertin, Hugo

Bonheur, Joel

Boukadida, Laurie

Boukerrou, Nadia

Chiesa, Patrizia

Colliot, Olivier

Dubois, Marion

Epelbaum, Stephane

Gagliardi, Geoffroy

Genthon, Remy

Houot, Marion

Kas, Aurelie

Lamari, Foudil

Levy, Marcel

Metzinger, Christiane

Mochel, Fanny

Nyasse, Francis

Poisson, Catherine

Revillon, Marie

Santos, Antonio

Andrade, Katia Santos

Sole, Marine

Surtee, Mohmed

de Schotten, Michel Thiebaud

Younsi, Nadjia

Afshar, Mohammad

Aguilar, Lisi Flores

Akman-Anderson, Leyla

Arenas, Joaquin

Avila, Jesus

Babiloni, Claudio

Baldacci, Filippo

Batrla, Richard

Benda, Norbert

Black, Keith L.

Bokde, Arun L. W.

Bonuccelli, Ubaldo

Broich, Karl

Cacciola, Francesco

机构：

[1] Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, APM,GRC 21, Blvd Hosp, Paris, France

[2] CNRS UMR 7225, INSERM U 1127, Brain & Spine Inst ICM, Blvd Hop, Paris, France

[3] Hop La Pitie Salpetriere, AP HP, Inst Memory & Alzheimers Dis IM2A, Dept Neurol, Paris, France

[4] UPMC, Hop Pitie Salpetriere, CNRS UMR7225, ICM,INSERM U1127, 47Bd Hop, Paris, France

[5] Sorbonne Univ, CNRS UMR, Lab Imagerie Biomed, INSERM U1146, Paris, France

[6] Hop La Pitie Salpetriere, AP HP, Dept Nucl Med, Paris, France

[7] CATI, Paris, France

[8] IRCCS Ctr San Giovanni Dio Fatebenefratelli, Lab Alzheimers Neuroimaging & Epidemiol, Brescia, Italy

[9] Sorbonne Univ, Brain Connect Behav Lab, Paris, France

[10] Univ Bordeaux, CNRS, CEA,UMR 5293, Grp Imagerie Neurofonct,Inst Malad Neurodegenerat, Bordeaux, France

来源：

ALZHEIMERS & DEMENTIA | 2019年 / 15卷 / 07期

基金：

欧洲研究理事会;

关键词：

Brain functional dynamics; Precision medicine; fMRI; Alzheimer's disease; Subjective memory complaints; INDEPENDENT COMPONENT ANALYSIS; RESTING-STATE FMRI; FUNCTIONAL CONNECTIVITY; MEMORY COMPLAINTS; APOLIPOPROTEIN-E; BRAIN ACTIVITY; APOE; BIOMARKER; ASSOCIATION; PRECUNEUS;

D O I：

10.1016/j.jalz.2019.03.006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: The longitudinal trajectories of functional brain dynamics and the impact of genetic risk factors in individuals at risk for Alzheimer's disease are poorly understood. Methods: In a large-scale monocentric cohort of 224 amyloid stratified individuals at risk for Alzheimer's disease, default mode network (DMN) resting state functional connectivity (FC) was investigated between two serial time points across 2 years. Results: Widespread DMN FC changes were shown in frontal and posterior areas, as well as in the right hippocampus. There were no cross-sectional differences, however, apolipoprotein E epsilon 4 (APOE epsilon 4) carriers demonstrated slower increase in FC in frontal lobes. There was no impact of individual brain amyloid load status. Discussion: For the first time, we demonstrated that the pleiotropic biological effect of the APOE epsilon 4 allele impacts the dynamic trajectory of the DMN during aging. Dynamic functional biomarkers may become useful surrogate outcomes for the development of preclinical targeted therapeutic interventions. (C) 2019 Published by Elsevier Inc. on behalf of the Alzheimer's Association.

引用

页码：940 / 950

页数：11

共 67 条

[1] Resting state fMRI in Alzheimer's disease: beyond the default mode network [J].