Differences Between Coronary Artery Calcification and Aortic Artery Calcification in Relation to Cardiovascular Disease Risk Factors in Japanese Men

被引：15

作者：

Kimani, Cecilia ^{[1
]}

Kadota, Aya ^{[1
,2
]}

Miura, Katsuyuki ^{[1
,2
]}

Fujiyoshi, Akira ^{[2
]}

Zaid, Maryam ^{[1
]}

Kadowaki, Sayaka ^{[2
]}

Hisamatsu, Takashi ^{[2
,3
,20
]}

Arima, Hisatomi ^{[4
,24
]}

Horie, Minoru ^{[5
,6
]}

Ueshima, Hirotsugu ^{[1
,2
]}

Yamamoto, Takashi ^{[6
]}

Maegawa, Hiroshi ^{[6
]}

Murata, Kiyoshi ^{[6
]}

Nozaki, Kazuhiko ^{[6
]}

Shiino, Akihiko ^{[6
]}

Toyama, Ikuo ^{[6
]}

Tsuru, Teruhiko ^{[6
]}

Ogita, Hisakazu ^{[6
]}

Takashima, Naoyuki ^{[6
]}

Kadowaki, Takashi ^{[6
]}

Miyamatsu, Naomi ^{[6
]}

Miyagawa, Naoko ^{[6
]}

Torii, Sayuki ^{[6
]}

Hayashi, Hideki ^{[6
]}

Nakano, Yasutaka ^{[6
]}

Ogawa, Emiko ^{[6
]}

Miyazawa, Itsuko ^{[6
]}

Shimizu, Akio ^{[6
]}

Abbott, Robert D. ^{[6
]}

Kondo, Keiko ^{[6
]}

Suzuki, Sentaro ^{[6
]}

Ito, Takahiro ^{[6
]}

Andoh, Akira ^{[6
]}

Kunimura, Ayako ^{[6
]}

Nishio, Yoshihiko ^{[7
]}

Mitsunami, Kenichi ^{[8
]}

Kita, Toru ^{[9
]}

Kimura, Takeshi ^{[9
]}

Tabara, Yasuharu ^{[9
]}

Nakamura, Yasuyuki ^{[10
]}

Okamura, Tomonori ^{[11
]}

Sekikawa, Akira ^{[12
]}

Barinas-Mitchell, Emma J. M. ^{[12
]}

Ohkubo, Takayoshi ^{[13
]}

Kita, Yoshikuni ^{[14
]}

Murakami, Yoshitaka ^{[15
]}

Hozawa, Atsushi ^{[16
]}

Okuda, Nagako ^{[17
]}

Higashiyama, Aya ^{[18
]}

Ohno, Seiko ^{[18
]}

机构：

[1] Shiga Univ Med Sci, Ctr Epidemiol Res Asia, Seta Tsukinowa Cho, Otsu, Shiga 5202192, Japan

[2] Shiga Univ Med Sci, Dept Publ Hlth, Otsu, Shiga, Japan

[3] Shimane Univ, Fac Med, Dept Environm Med & Publ Hlth, Matsue, Shimane, Japan

[4] Fukuoka Univ, Fac Med, Dept Prevent Med & Publ Hlth, Fukuoka, Fukuoka, Japan

[5] Shiga Univ Med Sci, Dept Internal Med, Otsu, Shiga, Japan

[6] Shiga Univ Med Sci, Otsu, Shiga, Japan

[7] Kagoshima Univ, Kagoshima, Japan

[8] Vories Mem Hosp, Omihachiman, Shiga, Japan

[9] Kyoto Univ, Kyoto, Japan

[10] Ryukoku Univ, Kyoto, Japan

[11] Keio Univ, Tokyo, Japan

[12] Univ Pittsburgh, Pittsburgh, PA USA

[13] Teikyo Univ, Tokyo, Japan

[14] Tsuruga Nursing Univ, Tsuruga, Fukui, Japan

[15] Toho Univ, Ota, Tokyo, Japan

[16] Tohoku Univ, Sendai, Miyagi, Japan

[17] Univ Human Arts & Sci, Iwatsuki Ku, Saitama, Japan

[18] Natl Cerebral & Cardiovasc Ctr, Res & Dev Initiat Ctr, Suita, Osaka, Japan

[19] Kanazawa Med Univ, Kanazawa, Ishikawa, Japan

[20] Shimane Univ, Matsue, Shimane, Japan

[21] Tokyo Med & Dent Univ, Tokyo, Japan

[22] Aino Univ, Takatsuki, Osaka, Japan

[23] Temple Univ, Philadelphia, PA 19122 USA

[24] Fukuoka Univ, Fukuoka, Fukuoka, Japan

[25] Keio Univ, Sch Med, Tokyo, Japan

[26] Doshisha Univ, Kyoto, Japan

[27] Shinshu Univ, Nagano, Japan

[28] Ehime Univ, Matsuyama, Ehime, Japan

来源：

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS | 2019年 / 26卷 / 05期

关键词：

Coronary artery; Aortic artery; Calcification; Cardiovascular diseases; Risk factors; SOCIETY JAS GUIDELINES; INTIMA-MEDIA THICKNESS; ALCOHOL-CONSUMPTION; SUBCLINICAL ATHEROSCLEROSIS; INFLAMMATORY MARKERS; COMPUTED-TOMOGRAPHY; ARCH CALCIFICATION; PROGNOSTIC VALUE; HEART-DISEASE; ALL-CAUSE;

D O I：

10.5551/jat.44784

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Aims: Calcification in the coronary and aortic arteries has been linked to cardiovascular morbidity and mortality. The pathophysiological influence of aortic artery calcification (AAC) differs from that of coronary artery calcification (CAC). We aimed to compare the relationships between CAC and AAC and cardiovascular disease (CVD) risk factors. Methods: We examined a random sample of 1035 Japanese men aged 40-79 years. CAC and AAC were measured by computed tomography and scored according to the Agatston method. Using a logistic regression, we calculated the odds ratio (OR) as being in the highest quintile (Q5) of the calcification score compared to the lower quintiles (Q1-Q4) per 1 standard deviation higher CVD risk factor. Models were simultaneously adjusted for age, body mass index (BMI), systolic blood pressure, smoking (pack-year), alcohol intake, hemoglobin A1c, uric acid, estimated glomerular filtration rate (eGFR), serum lipids, and C-reactive protein. Differences in ORs were investigated using a generalized estimating equation. We performed a multiple linear regression using log-transformed CAC and AAC values as dependent variables. Results: CAC and AAC were independently associated with age (OR, 95% CI: 2.30 [1.77-2.98] for CAC and 3.48 [2.57-4.73] for AAC), p for difference < 0.001), systolic blood pressure (1.29 [1.08-1.53] and 1.28 [1.07-1.54], p for difference = 0.270), and smoking (1.22, [1.04-1.43] and 1.34 [1.13-1.58]) p for difference = 0.071). Alcohol correlated with AAC only (1.17 [0.97-1.41] for CAC and 1.42 [1.16-1.73] for AAC, p for difference = 0.020). Conclusions: CAC and AAC were associated with similar CVD risk factors. The strength of association slightly differed between CAC and AAC.

引用

页码：452 / 464

页数：13

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