Current State and Future Perspectives on Gastroretentive Drug Delivery Systems

被引：131

作者：

Tripathi, Julu ^{[1
]}

Thapa, Prakash ^{[1
]}

Maharjan, Ravi ^{[1
]}

Jeong, Seong Hoon ^{[1
]}

机构：

[1] Dongguk Univ Seoul, Coll Pharm, 32 Donggukro, Goyang 10326, Gyeonggi, South Korea

来源：

PHARMACEUTICS | 2019年 / 11卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

gastroretentive drug delivery systems; gastric retention time; narrow absorption window; bioavailability; polymer; HYDRODYNAMICALLY BALANCED SYSTEM; EXCHANGE-RESIN COMPLEXES; GASTRIC RESIDENCE TIME; IN-VITRO EVALUATION; SUSTAINED-RELEASE; DOSAGE FORMS; FLOATING TABLETS; ALGINATE BEADS; GASTROINTESTINAL TRANSIT; MUCOADHESIVE;

D O I：

10.3390/pharmaceutics11040193

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In recent years, many attempts have been made to enhance the drug bioavailability and therapeutic effectiveness of oral dosage forms. In this context, various gastroretentive drug delivery systems (GRDDS) have been used to improve the therapeutic efficacy of drugs that have a narrow absorption window, are unstable at alkaline pH, are soluble in acidic conditions, and are active locally in the stomach. In this review, we discuss the physiological state of the stomach and various factors that affect GRDDS. Recently applied gastrointestinal technologies such as expandable, superporous hydrogel; bio/mucoadhesive, magnetic, ion-exchange resin; and low- and high-density-systems have also been examined along with their merits and demerits. The significance of in vitro and in vivo evaluation parameters of various GRDDS is summarized along with their applications. Moreover, future perspectives on this technology are discussed to minimize the gastric emptying rate in both the fasted and fed states. Overall, this review may inform and guide formulation scientists in designing the GRDDS.

引用

页数：22

共 109 条

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