Vancomycin and oxacillin synergy for methicillin-resistant staphylococci

被引：40

作者：

Domaracki, BE ^{[1
]}

Evans, AM ^{[1
]}

Venezia, RA ^{[1
]}

机构：

[1] Albany Med Ctr, Dept Lab Med & Pathol, Albany, NY 12208 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 05期

关键词：

D O I：

10.1128/AAC.44.5.1394-1396.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An increase in oxacillin activity was observed against methicillin-resistant coagulase-negative staphylococci (MRCNS) and methicillin-resistant Staphylococcus aureus (MRSA) in the presence of a sub-MIC of vancomycin. Vancomycin and oxacillin were synergistic against 14 of 21 strains of MRCNS and MRSA. A pattern of enhanced killing was also supported by time-kill studies. These results suggest that combinations of sub-MICs of vancomycin and oxacillin may have therapeutic benefits against methicillin-resistant staphylococci.

引用

页码：1394 / 1396

页数：3

共 15 条

[1] Activities of levofloxacin, ofloxacin, and ciprofloxacin, alone and in combination with amikacin, against acinetobacters as determined by checkerboard and time-kill studies [J].

Bajaksouzian, S ;

Visalli, MA ;

Jacobs, MR ;

Appelbaum, PC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (05) :1073-1076

[2] DEVELOPMENT OF INVITRO RESISTANCE TO GLYCOPEPTIDE ANTIBIOTICS - ASSESSMENT IN STAPHYLOCOCCI OF DIFFERENT SPECIES [J].

BIAVASCO, F ;

GIOVANETTI, E ;

MONTANARI, MP ;

LUPIDI, R ;

VARALDO, PE .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1991, 27 (01) :71-79

[3]

Centers for Disease Control and Prevention (CDC), 1997, MMWR Morb Mortal Wkly Rep, V46, P813

[4]

Centers for Disease Control and Prevention (CDC), 1997, MMWR MORB MORTAL WKL, V46, P765

[5]

Domaracki BE, 1998, EUR J CLIN MICROBIOL, V17, P143

[6] INVITRO SELECTION OF RESISTANCE TO VANCOMYCIN IN BLOOD-STREAM ISOLATES OF STAPHYLOCOCCUS-HAEMOLYTICUS AND STAPHYLOCOCCUS-EPIDERMIDIS [J].

HERWALDT, L ;

BOYKEN, L ;

PFALLER, M .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1991, 10 (12) :1007-1012

[7] Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility [J].

Hiramatsu, K ;

Hanaki, H ;

Ino, T ;

Yabuta, K ;

Oguri, T ;

Tenover, FC .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1997, 40 (01) :135-136

[8]

*NAT COMM CLIN LAB, 1996, M7A4 NAT COMM CLIN L

[9] EMERGENCE OF VANCOMYCIN RESISTANCE IN COAGULASE-NEGATIVE STAPHYLOCOCCI [J].

SCHWALBE, RS ;

STAPLETON, JT ;

GILLIGAN, PH .

NEW ENGLAND JOURNAL OF MEDICINE, 1987, 316 (15) :927-931

[10] SELECTION FOR VANCOMYCIN RESISTANCE IN CLINICAL ISOLATES OF STAPHYLOCOCCUS-HAEMOLYTICUS [J].

SCHWALBE, RS ;

RITZ, WJ ;

VERMA, PR ;

BARRANCO, EA ;

GILLIGAN, PH .

JOURNAL OF INFECTIOUS DISEASES, 1990, 161 (01) :45-51

← 1 2 →