Assessment of treatment efficacy of diphenylcyclopropenone (DPCP) for alopecia areata

被引:7
作者
Kutlubay, Zekayi [1 ]
Sevim Kecici, Aysegul [2 ]
Aydin, Ovgu [3 ]
Vehid, Suphi [4 ]
Serdaroglu, Server [1 ]
机构
[1] Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Dept Dermatol, Istanbul, Turkey
[2] Univ Med Sci, Haydarpasa Numune Training & Res Hosp, Dept Dermatol, Istanbul, Turkey
[3] Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Dept Pathol, Istanbul, Turkey
[4] Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Dept Biostat, Istanbul, Turkey
关键词
Alopecia areata; topical immunotherapy; diphenylcyclopropenone; TOPICAL IMMUNOTHERAPY; PROGNOSTIC-FACTORS; IMMUNE PRIVILEGE; HAIR FOLLICLE; DIPHENCYPRONE; COMBINATION; SAFETY;
D O I
10.3906/sag-1807-230
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background/aim: Alopecia areata (AA) is an inflammatory disease with a genetic and autoimmtme basis. Herein, it was aimed to study the efficacy and safety of an immunomodulatory therapeutic agent, diphenylcyclopropenone, while manifesting its association with histopathological features, prognostic factors, and side effects. Materials and methods: In this retrospective study, 98 patients (60 males, 38 females) with alopecia, who were referred to the Hair Disease Polyclinic at the Department of Dermatology, between 2011 and 2015, were included. Together with medical histories and dermatological examinations, a skin biopsy for histopathological examination was conducted for all of the patients prior to therapy. herapeutic success was evaluated on the basis of the hair regrowth percentage. Results: Regarding the overall treatment success, 33 (34%) patients had complete response, 16 (16%) had partial response (between 50% and 99%), 27 (28%) had minimal response (between 1% and 49%), and 22 (22%) were nonresponders. Both scxs were equally represented in the outcome. Conclusions: There was a significant relation between the severity of alopecia and the treatment outcome (P = 0.038). Patients with AA had significantly better response when compared to those with alopecia totalis and universalis. There was no statistically significant relation with other parameters, such as disease duration, age, sex, atopy history, age of onset, and histopathological features.
引用
收藏
页码:1817 / 1824
页数:8
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