Wavelet analysis of DNA walks

被引：29
作者：
Haimovich, Adrian D.
Byrne, Bruce
Ramaswamy, Ramakrishna
Welsh, William J.
机构：
[1] Univ Med & Dent New Jersey, Inst Informat, Newark, NJ 07101 USA
[2] Inst Adv Study, Ctr Syst Biol, Princeton, NJ 08540 USA
[3] Jawaharlal Nehru Univ, Sch Phys Sci, New Delhi 110067, India
[4] Jawaharlal Nehru Univ, Sch Informat Technol, Ctr Computat Biol & Bioinformat, New Delhi 110067, India
[5] Univ Med & Dent New Jersey, Dept Pharmacol, New Brunswick, NJ 07103 USA
来源：
JOURNAL OF COMPUTATIONAL BIOLOGY | 2006年 / 13卷 / 07期
关键词：
DNA walk; genomic analysis; sequence analysis; wavelet transform;
D O I：
10.1089/cmb.2006.13.1289
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A wavelet transform of the DNA "walk" constructed from a genomic sequence offers a direct visualization of short and long-range patterns in nucleotide sequences. We study sequences that encode diverse biological functions, taken from a variety of genomes. Pattern irregularities in the transform are frequently associated with sequences of biological interest. Exonic regions, for example, visualize differently under wavelet analysis than introns, and ribosomal RNA regions display distinct universal signatures. DNA walk wavelet analysis can provide a sensitive and rapid assessment of the putative biological significance of genomic DNA.
引用
收藏
页码：1289 / 1298
页数：10
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