Iridium-Catalyzed Asymmetric Isomerization of Primary Allylic Alcohols

被引：128

作者：

Mantilli, Luca ^{[1
]}

Gerard, David ^{[1
]}

Torche, Sonya ^{[1
]}

Besnard, Celine ^{[2
]}

Mazet, Clement ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

[2] Univ Geneva, Lab Cristallog, CH-1211 Geneva 4, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 28期

关键词：

allylic compounds; asymmetric catalysis; iridium; isomerization; P; N ligands; ENANTIOSELECTIVE ISOMERIZATION; HOMOGENEOUS HYDROGENATION; CARBONYL-COMPOUNDS; HYDROXYL GROUP; X-RAY; COMPLEXES; LIGANDS; OLEFINS; MECHANISM; ALDEHYDES;

D O I：

10.1002/anie.200901863

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nothing to sm(Ir)k at: Under appropriate reaction conditions, iridium hydride catalysts promote the isomerization of primary allylic alcohols. The best catalysts, like (R)-1 (P green, O red, N blue, Ir yellow), deliver the desired chiral aldehydes with excellent enantioselectivity and good yields. Mechanistic hypotheses have been developed on the basis of preliminary investigations. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5143 / 5147

页数：5

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