TRAIL of Hope Meeting Resistance in Cancer

被引：114
作者：
Deng, David [1 ,2 ]
Shah, Khalid [1 ,2 ,3 ]
机构：
[1] Harvard Med Sch, Ctr Stem Cell Therapeut & Imaging, Brigham & Womens Hosp, Boston, MA 02129 USA
[2] Harvard Med Sch, Brigham & Womens Hosp, Dept Neurosurg, Boston, MA 02129 USA
[3] Harvard Univ, Harvard Stem Cell Inst, Cambridge, MA 02138 USA
来源：
TRENDS IN CANCER | 2020年 / 6卷 / 12期
基金：
美国国家卫生研究院;
关键词：
RECEPTOR-SELECTIVE MUTANTS; INDUCED APOPTOSIS; TUMORICIDAL ACTIVITY; DEATH RECEPTORS; DOWN-REGULATION; SURFACE EXPRESSION; ANTITUMOR EFFICACY; MELANOMA CELLS; CROSS-LINKING; TNF-ALPHA;
D O I：
10.1016/j.trecan.2020.06.006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis selectively via its interaction with the death receptors TRAILR1/DR4 and TRAILR2/DR5 in a wide range of cancers, while sparing normal cells. Despite its tremendous potential for cancer therapeutics, the translation of TRAIL into the clinic has been confounded by TRAIL-resistant cancer populations. We discuss different molecular mechanisms underlying TRAIL-mediated apoptosis and resistance to TRAIL. We also discuss the successes and failures of recent preclinical and clinical studies of TRAIL-induced apoptosis, and current attempts to overcome TRAIL resistance, and we provide a perspective for improving the prospects of future clinical implementation.
引用
收藏
页码：989 / 1001
页数：13
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