Conversion of 5-aryl-3-phenylthio-2(3H)-furanones into some nitrogen- and sulphur-containing heterocycles

被引：5

作者：

Youssef, Ahmed S. A. ^{[1
]}

Kandeel, Kamal A. ^{[1
]}

Abou-Elmagd, Wael S. I. ^{[1
]}

Hashem, Ahmed I. ^{[1
]}

机构：

[1] Ain Shams Univ, Fac Sci, Dept Chem, Cairo, Egypt

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2007年 / 182卷 / 01期

关键词：

2(3H)-furanones; 1,3,4-oxadiazales; 2(3H)-pyrrolones; pyridazinones; 1,2,4-triazolones;

D O I：

10.1080/10426500600867349

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

3-Phenylthio-5-aryl-2(3H)-furanones 4 were prepared from 2-phenylthio-3-aroylpropionic acids 3 by a ring closure using acetic anhydride. Benzylamine reacted with 4 to give the benzylamide derivatives 5, which were cyclized to the corresponding 2(3H)-pyrrolones 6. The isothiazolone derivatives 7 were obtained from the benzylamides 5 by the action of SOCl2. A ring opening of furanone 4 with hydrazine hydrate gave the acid hydrazides 8. The latter hydrazides were utilized as starting materials for the synthesis of pyridazinone derivatives 9 and 11, 1,3,4-oxadiazoles 13, and triazolone derivatives 14.

引用

页码：85 / 97

页数：13

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[2]

BINDER D, 1987, EUR PAT, V19, P173

[3]

COJOCARIU I, 1977, REV CHIM, V28, P15

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