Gastrointestinal stromal tumor of the prostate: a case report and literature review

被引:47
作者
Lee, Chii-Hong
Lin, Yun-Ho
Lin, Hsiao-Yu
Lee, Chi-Ming
Chu, Jan-Show [1 ]
机构
[1] Taipei Med Univ Hosp, Dept Pathol, Taipei 110, Taiwan
[2] Taipei Med Univ Hosp, Dept Urol, Taipei 110, Taiwan
[3] Taipei Med Univ Hosp, Dept Radiol, Taipei 110, Taiwan
[4] Taipei Med Univ, Sch Med, Dept Pathol, Taipei 110, Taiwan
关键词
prostate; GIST; sarcoma; KIT;
D O I
10.1016/j.humpath.2006.06.028
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
We report a case of gastrointestinal stromal tumor (GIST) of the prostate in a 75-year-old man with dysuria and urinary retention. Digital rectal examination revealed a markedly enlarged prostate. The serum level of prostate-specific antigen was 0.2 ng/dL. Imaging studies showed an expanded prostate, measuring 6.7 x 5.6 x 5.5 cm, with heterogeneity in contrast enhancement. No metastatic disease was found. The pathologic diagnosis of prostatic GIST was made based on characteristic morphological features, immunoprofiles, and molecular analysis. The possibility of secondary involvement by a rectal GIST was excluded by radiological and intraoperative findings. To our knowledge, this is the second case of a primary GIST of the prostate reported in the literature. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:1361 / 1365
页数:5
相关论文
共 15 条
[11]   Extragastrointestinal (Soft tissue) stromal tumors: An analysis of 48 cases with emphasis on histologic predictors of outcome [J].
Reith, JD ;
Goldblum, JR ;
Lyles, RH ;
Weiss, SW .
MODERN PATHOLOGY, 2000, 13 (05) :577-585
[12]   GIST: An update [J].
Rosai, J .
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 2003, 11 (03) :177-186
[13]   Gastrointestinal stromal tumor of the prostate [J].
Van der Aa, F ;
Sciot, R ;
Blyweert, W ;
Ost, D ;
Van Poppel, H ;
Van Oosterom, A ;
Debiec-Rychter, M ;
De Ridder, D .
UROLOGY, 2005, 65 (02) :E10-E11
[14]   Interstitial cells in the human prostate: A new therapeutic target? [J].
Van der Aa, F ;
Roskams, T ;
Blyweert, W ;
De Ridder, D .
PROSTATE, 2003, 56 (04) :250-255
[15]   Uterine gastrointestinal stromal tumour (GIST) [J].
Wingen, CBM ;
Pauwels, PAA ;
Debiec-Rychter, M ;
van Gemert, WG ;
Vos, MC .
GYNECOLOGIC ONCOLOGY, 2005, 97 (03) :970-972