Proteomic definitions of basement membrane composition in health and disease

被引：101
作者：
Randles, Michael J. [1 ,2 ]
Humphries, Martin J. [1 ]
Lennon, Rachel [1 ,2 ,3 ]
机构：
[1] Univ Manchester, Fac Life Sci, Wellcome Trust Ctr Cell Matrix Res, Manchester, Lancs, England
[2] Univ Manchester, Fac Med & Human Sci, Inst Human Dev, Manchester, Lancs, England
[3] MAHSC, Cent Manchester Univ Hosp NHS Fdn Trust CMFT, Dept Paediat Nephrol, Manchester, Lancs, England
来源：
MATRIX BIOLOGY | 2017年 / 57-58卷
基金：
英国惠康基金;
关键词：
Extracellular matrix; Proteomics; Glycoproteomics; Degradomics; Mass spectrometry; Quantification; Fractionation; Enrichment; Bioinformatics; Systems biology; MASS-SPECTROMETRIC IDENTIFICATION; GLOMERULAR EXTRACELLULAR-MATRIX; PROTEIN N-TERMINI; COLLAGEN-IV; ALPORT-SYNDROME; IN-VIVO; PEPTIDES; LAMININ; NEPHROPATHY; TISSUE;
D O I：
10.1016/j.matbio.2016.08.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Basement membranes are formed from condensed networks of extracellular matrix (ECM) proteins. These structures underlie all epithelial, mesothelial and endothelial sheets and provide an essential structural scaffold. Candidate-based investigations have established that predominant components of basement membranes are laminins, collagen type IV, nidogens and heparan sulphate proteoglycans. More recently, global proteomic approaches have been applied to investigate ECM and these analyses confirm tissue-specific ECM proteomes with a high degree of complexity. The proteomes consist of structural as well as regulatory ECM proteins such as proteases and growth factors. This review is focused on the proteomic analysis of basement membranes and illustrates how this approach can be used to build our understanding of ECM regulation in health and disease. Crown Copyright (C) 2016 Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：12 / 28
页数：17
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