Progress in spondylarthritis Mechanisms of new bone formation in spondyloarthritis

被引：162
作者：
Lories, Rik J. U. [1 ]
Luyten, Frank P. [1 ]
de Vlam, Kurt [1 ]
机构：
[1] Katholieke Univ Leuven, Dept Musculoskeletal Sci, Div Rheumatol, Lab Skeletal Dev & Joint Disorders, Louvain, Belgium
来源：
ARTHRITIS RESEARCH & THERAPY | 2009年 / 11卷 / 02期
关键词：
NECROSIS-FACTOR-ALPHA; GROWTH-FACTOR-BETA; ANKYLOSING-SPONDYLITIS; PSORIATIC-ARTHRITIS; RADIOGRAPHIC PROGRESSION; DEVELOPMENTAL REGULATION; CARTILAGE DESTRUCTION; ARTICULAR-CARTILAGE; CLINICAL-TRIAL; MOUSE MODEL;
D O I：
10.1186/ar2642
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Targeted therapies that neutralize tumour necrosis factor are often able to control the signs and symptoms of spondyloarthritis. However, recent animal model data and clinical observations indicate that control of inflammation may not be sufficient to impede disease progression toward ankylosis in these patients. Bone morphogenetic proteins and WNTs (wingless-type like) are likely to play an important role in ankylosis and could be therapeutic targets. The relationship between inflammation and new bone formation is still unclear. This review summarizes progress made in our understanding of ankylosis and offers an alternative view of the relationship between inflammation and ankylosis.
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页数：8
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