Templated Self-Replication in Biomimetic Systems

被引：27

作者：

Le Vay, Kristian ^{[1
]}

Weise, Laura Isabel ^{[1
]}

Libicher, Kai ^{[1
]}

Mascarenhas, Judita ^{[2
]}

Mutschler, Hannes ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Biomimet Syst, Martinsried, Germany

[2] Max Planck Inst Terr Microbiol, Dept Syst & Synthet Microbiol, Marburg, Germany

来源：

ADVANCED BIOSYSTEMS | 2019年 / 3卷 / 06期

关键词：

autocatalysis; in vitro systems; origin of life; self-replication; synthetic biology; IN-VITRO AMPLIFICATION; RNA-POLYMERASE; DNA-POLYMERASE; RIBOSOMAL-RNA; PRIMER EXTENSION; AUTOCATALYTIC SYNTHESIS; INTERVENING SEQUENCE; STRUCTURALLY COMPLEX; NUCLEIC-ACIDS; SPLICING RNA;

D O I：

10.1002/adbi.201800313

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

A key characteristic of living systems is the storage and replication of information, and as such the development of self-replicating systems capable of heredity is of great importance to the fields of synthetic biology and origin of life research. In this review, the design and implementation of self-replicating systems in the context of bottom-up synthetic biology is discussed, with a particular focus on nucleic acid-based replication including nonenzymatic systems, ribozyme-based systems, and complex in vitro translation coupled RNA and DNA replication. The current state and remaining challenges of the respective fields are discussed, and the potential of individual replicators for synthetic biology applications such as the creation of artificial life capable of Darwinian evolution is also summarized.

引用

页数：16

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