Biologics in Inflammatory Immune-mediated Systemic Diseases

被引：20
|
作者：
Moroncini, Gianluca [1 ]
Calogera, Giovanni [1 ]
Benfaremo, Devis [1 ]
Gabrielli, Armando [1 ]
机构：
[1] Univ Politecn Marche, Dipartimento Sci Clin & Mol, Clin Med, Via Tronto 10-A, I-60126 Ancona, Italy
来源：
CURRENT PHARMACEUTICAL BIOTECHNOLOGY | 2017年 / 18卷 / 12期
关键词：
ANCA-associated vasculitis; Behcet Disease; belimumab; rituximab; Systemic Lupus Erythematosus (SLE); Systemic Sclerosis (SSc); TNF-inhibitors; tocilizumab; RANDOMIZED CONTROLLED-TRIAL; ONSET STILLS-DISEASE; GIANT-CELL ARTERITIS; LOW-DOSE RITUXIMAB; ANTI-TNF AGENTS; DOUBLE-BLIND; RHEUMATOID-ARTHRITIS; BEHCETS-DISEASE; LUPUS-ERYTHEMATOSUS; MONOCLONAL-ANTIBODY;
D O I：
10.2174/1389201019666171226152448
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Background: The use of biologic agents in systemic immune-mediated diseases has dramatically increased in recent years, replacing conventional immunosuppressive strategies that are characterized by unspecific mechanisms of action and burdened with serious adverse effects. Biologic drugs have selective action towards specific targets, with considerable steroid-sparing effect. They are used nowadays to induce remission or treat specific organ involvements in systemic autoimmune diseases. Conclusion: In this review, we will discuss the scientific evidence supporting the use of biologics in these diseases, with a particular emphasis on their efficacy and safety profile compared to the conventional drugs.
引用
收藏
页码：1008 / 1016
页数：9
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