Myoglobin Removal Using High-Volume High-Flux Hemofiltration in Patients with Oliguric Acute Kidney Injury

被引：7

作者：

Guzman, Nelio

Podoll, Amber S.

Bell, Cynthia S.

Finkel, Kevin W.

机构：

[1] UT Hlth Sci Ctr Houston, Sch Med, Div Renal Dis & Hypertens, Div Pediat Nephrol,Dept Internal Med, Houston, TX 77030 USA

[2] UT Hlth Sci Ctr Houston, Sch Med, Div Renal Dis & Hypertens, Div Pediat Nephrol,Dept Pediat, Houston, TX 77030 USA

来源：

BLOOD PURIFICATION | 2013年 / 36卷 / 02期

关键词：

Acute renal failure; Continuous venovenous hemofiltration; Rhabdomyolysis; Solute clearance; Myoglobinemia; CONTINUOUS VENOVENOUS HEMOFILTRATION; ACUTE-RENAL-FAILURE; CASE SERIES; SEVERE RHABDOMYOLYSIS; CLEARANCE; HEMODIAFILTRATION;

D O I：

10.1159/000354727

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Rhabdomyolysis can cause acute kidney injury (AKI). It remains controversial whether or not myoglobin can be removed from the circulation with extracorporeal therapy and decrease the incidence of AKI. Therefore, we examined myoglobin removal in a series of 11 patients with oliguric AKI treated with high-volume hemofiltration. Methods: Patients received prefilter hemofiltration using a polysulphone filter with a molecular size cutoff of 65 kDa and a surface area of 1.7 m(2). Sieving coefficients and myoglobin clearances were calculated at 6, 12, and 24 h after the start of hemofiltration. Results: The mean sieving coefficient was 0.158, and the mean myoglobin clearance was 8.7 ml/min. Conclusion: Despite the use of high-volume hemofiltration, the removal of myoglobin was negligible. In patients with normal renal function, the anticipated amount of extracorporeal removal would not significantly impact renal exposure to myoglobin. (C) 2013 S. Karger AG, Basel

引用

页码：107 / 111

页数：5

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