Epigenetic agents in combined anticancer therapy

被引：16

作者：

Kejik, Zdenek ^{[1
]}

Jakubek, Milan ^{[2
,3
]}

Kaplanek, Robert ^{[2
,3
]}

Kralova, Jarmila ^{[1
]}

Mikula, Ivan ^{[1
]}

Martasek, Pavel ^{[2
]}

Kral, Vladimir ^{[1
,2
,3
]}

机构：

[1] Charles Univ Prague, Fac Med 1, Katerinska 32, Prague 12108 2, Czech Republic

[2] Charles Univ Prague, Fac Med 1, BIOCEV, Vestec 25250, Czech Republic

[3] Univ Chem & Technol, Fac Chem Engn, Dept Analyt Chem, Tech 5, Prague 16628 6, Czech Republic

来源：

FUTURE MEDICINAL CHEMISTRY | 2018年 / 10卷 / 09期

关键词：

anticancer treatment; combination therapy; epigenetic agents; HISTONE DEACETYLASE INHIBITOR; CELL LUNG-CANCER; SUBEROYLANILIDE HYDROXAMIC ACID; DNA METHYLATION; VALPROIC ACID; BREAST-CANCER; SYNERGISTIC COMBINATION; ONCOLYTIC ADENOVIRUS; ANTITUMOR EFFICACY; INDUCED APOPTOSIS;

D O I：

10.4155/fmc-2017-0203

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the last decade, epigenetic drugs (such as inhibitors of DNA methyltransferases and histone deacetylases) have been intensively used for cancer treatment. Their applications have shown high anticancer effectivity and tolerable side effects. However, they are unfortunately not effective in the treatment of some types and phenotypes of cancers. Nevertheless, several studies have demonstrated that problems of drug efficacy can be overcome through the combined application of therapeutic modulates. Therefore, combined applications of epigenetic agents with chemotherapy, radiation therapy, immunotherapy, oncolytic virotherapy and hyperthermia have been presented. This review summarizes and discusses the general principles of this approach, as introduced and supported by numerous examples. In addition, predictions of the future potential applications of this methodology are included.

引用

页码：1113 / 1130

页数：18

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