Alkaloids and polyketides from the South China Sea sponge Agelas aff. nemoechinata

被引：15

作者：

An, Liang ^{[1
,3
]}

Song, Wenjuan ^{[1
,2
]}

Tang, Xuli ^{[4
]}

de Voogd, Nicole J. ^{[5
]}

Wang, Qi ^{[1
,2
]}

Chu, Meijun ^{[1
,2
]}

Li, Pinglin ^{[1
,2
]}

Li, Guoqiang ^{[1
,2
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

[2] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Shandong, Peoples R China

[3] Qingdao Huanghai Pharmaceut Co Ltd, Qingdao 266101, Peoples R China

[4] Ocean Univ China, Coll Chem & Chem Engn, Qingdao 266100, Peoples R China

[5] Natl Museum Nat Hist, NL-2300 RA Leiden, Netherlands

来源：

RSC ADVANCES | 2017年 / 7卷 / 24期

基金：

中国国家自然科学基金;

关键词：

B METHYL-ESTER; BROMOPYRROLE ALKALOIDS; BIOLOGICAL EVALUATION; METABOLITES; DERIVATIVES; MAURITIANA; LONGAMIDE;

D O I：

10.1039/c6ra27026c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A chemical investigation of the South China Sea sponge Agelas aff. nemoechinata yielded three pairs of new enantiotopic pyrrole alkaloids nemoechines A-C (1-3), one new diterpene-adenine alkaloid nemoechine D (8), and one new polyketide nemoechioxide A (10), together with nine known analogues (4-7, 9, 11-14). Compounds 1-3 were initially obtained as racemates and were further separated by chiral HPLC chromatography to afford the three pairs of enantiomers. Their structures including absolute configurations of compounds 1-3 were elucidated on the basis of comprehensive spectroscopic analysis and quantum chemical calculation. Nemoechine A (1), possessing an unusual cyclopentane-fused imidazole ring system, represents the first monomeric precursor of nagelamide J. Compounds 8 and 9 showed cytotoxicity against HL-60 cell lines with IC50 values of 9.9 and 0.9 mu M, respectively, and compound 9 was also cytotoxic against HeLa cell lines with IC50 value of 8.9 mu M.

引用

页码：14323 / 14329

页数：7

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