Observation of size-dependent melting in lipid nanoparticles

被引：55

作者：

Unruh, T

Bunjes, H

Westesen, K

Koch, MHJ

机构：

[1] Univ Jena, Inst Pharm Pharmazeut Technol, D-07743 Jena, Germany

[2] DESY, European Mol Biol Lab, Hamburg Outstn, D-22603 Hamburg, Germany

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 1999年 / 103卷 / 47期

关键词：

D O I：

10.1021/jp9912612

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The differential scanning calorimetry thermograms of suspensions of trimyristin nanoparticles in the stable P-polymorph display several melting events. Particle thickness distributions obtained by analysis of difference X-ray diffraction patterns recorded during melting reveal that these discrete events correspond to the melting of classes of particles differing in thickness by only one unit cell. A large increase in lattice constants with decreasing particle thickness was observed, indicating that classical surface thermodynamics is not applicable to particles consisting of only a few molecular layers.

引用

页码：10373 / 10377

页数：5