Observation of size-dependent melting in lipid nanoparticles

被引：55
作者：
Unruh, T
Bunjes, H
Westesen, K
Koch, MHJ
机构：
[1] Univ Jena, Inst Pharm Pharmazeut Technol, D-07743 Jena, Germany
[2] DESY, European Mol Biol Lab, Hamburg Outstn, D-22603 Hamburg, Germany
来源：
JOURNAL OF PHYSICAL CHEMISTRY B | 1999年 / 103卷 / 47期
关键词：
D O I：
10.1021/jp9912612
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The differential scanning calorimetry thermograms of suspensions of trimyristin nanoparticles in the stable P-polymorph display several melting events. Particle thickness distributions obtained by analysis of difference X-ray diffraction patterns recorded during melting reveal that these discrete events correspond to the melting of classes of particles differing in thickness by only one unit cell. A large increase in lattice constants with decreasing particle thickness was observed, indicating that classical surface thermodynamics is not applicable to particles consisting of only a few molecular layers.
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页码：10373 / 10377
页数：5
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