HMG-CoA reductase inhibitors (statins), inflammation, and endothelial progenitor cells-New mechanistic insights of atherosclerosis

被引：32
作者：
Blum, Arnon [1 ,2 ]
机构：
[1] Bar Ilan Univ, Baruch Padeh Poria Hosp, Dept Med, IL-15208 Lower Galilee, Israel
[2] Bar Ilan Univ, Fac Med, IL-15208 Lower Galilee, Israel
来源：
BIOFACTORS | 2014年 / 40卷 / 03期
关键词：
endothelial stem cells; atherosclerosis; inflammation; C-REACTIVE PROTEIN; CORONARY-ARTERY-DISEASE; NITRIC-OXIDE SYNTHASE; IMPROVES CARDIAC-FUNCTION; E-DEFICIENT MICE; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; POSTMENOPAUSAL WOMEN; FAMILIAL HYPERCHOLESTEROLEMIA; OXIDATIVE MODIFICATION;
D O I：
10.1002/biof.1157
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Statins have been shown to favorably affect the prognosis of patients with risk factors to atherosclerosis-both as a primary and a secondary prevention. The beneficial effects observed with statin therapy are not merely related to changes in lipid profile but also are due to a positive effect on vascular inflammation and on immune-modulation of T lymphocytes and endothelial progenitor stem cells (EPCs). This dual effect has been demonstrated mainly in clinical trials where a change in endothelial function was observed within hours, much earlier than the effects of statins on the lipid profile (weeks). Based on all the knowledge that we have today questions were raised as to the mechanistic pathways that may explain the process of atherosclerosis and through this pathway to find better solutions and therapies to prevent and fight atherosclerosis. Our review will focus on the new updates in the field of inflammation and stem cells in vascular biology-in relation with atherosclerosis. (C) 2014 BioFactors
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收藏
页码：295 / 302
页数：8
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