Comprehensive characterization of the tumor microenvironment for assessing immunotherapy outcome in patients with head and neck squamous cell carcinoma

被引：0

作者：

Zhang, Jian ^{[1
,2
]}

Zhong, Xi ^{[3
]}

Jiang, Huali ^{[4
]}

Jiang, Hualong ^{[5
]}

Xie, Tao ^{[1
,2
]}

Tian, Yunhong ^{[1
,2
]}

Li, Rong ^{[1
,2
]}

Wang, Baiyao ^{[1
,2
]}

Zhang, Jiexia ^{[6
]}

Yuan, Yawei ^{[1
,2
]}

机构：

[1] Guangzhou Med Univ, Affiliated Canc Hosp & Inst, Dept Radiat Oncol, Guangzhou 510095, Peoples R China

[2] Guangzhou Inst Resp Dis, State Key Lab Resp Dis, Guangzhou 510095, Peoples R China

[3] Guangzhou Med Univ, Radiat Dept, Affiliated Canc Hosp & Inst, Guangzhou 510095, Peoples R China

[4] Sun Yat Sen Univ, Dept Cardiovascularol, Tungwah Hosp, Dongguan 523000, Peoples R China

[5] Sun Yat Sen Univ, Dept Urol, Tungwah Hosp, Dongguan 523000, Peoples R China

[6] Guangzhou Med Univ, State Key Lab Resp Dis, Natl Clin Res Ctr Resp Dis, Guangzhou Inst Resp Hlth,Affiliated Hosp 1, Guangzhou 510120, Peoples R China

来源：

AGING-US | 2020年 / 12卷 / 22期

关键词：

head and neck squamous cell carcinoma; tumor microenvironment; immunotherapy; single nucleotide variants; copy number variations; PD-1; BLOCKADE; MUTATIONAL PROCESSES; BREAST-CANCER; COPY-NUMBER; EXPRESSION; RECURRENT; PEMBROLIZUMAB; LANDSCAPE; NIVOLUMAB; SIGNATURES;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The tumor microenvironment (TME) constitutes a complex milieu of cells and cytokines that maintain equilibrium between tumor progression and prognosis. However, comprehensive analysis of the TME and its clinical significance in head and neck squamous cell carcinoma (HNSCC) remains to be unreported. In this study, based on large-scale RNA sequencing data pertaining to single nucleotide variants (SNVs) and copy number variations (CNVs) in HNSCC patients from The Cancer Genome Atlas database, we analysed subpopulations of infiltrating immune cells and evaluated the role of TME infiltration pattern (TME score) in assessing immunotherapy outcome. TME signature genes involved in several inflammation and immunity signalling pathways were observed in the TME score subtype, which were considered immunosuppressive and potentially responsible for significantly worse prognosis. In comparison with SNVand CNV-mediated tumor mutation burden, TME score can significantly differentiate between highand low-risk HNSCC and predict immunotherapy outcome. Our data provide clarity on the comprehensive landscape of interactions between clinical characteristics of HNSCC and tumor-infiltrating immune cells. TME score seems to be a useful biomarker that can predict immunotherapy outcome in HNSCC patients.

引用

页码：22509 / 22526

页数：18

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