Differential effects of Th1 and Th2 derived cytokines on NGF synthesis by mouse astrocytes

被引：72

作者：

Brodie, C

机构：

[1] Department of Life Sciences, Bar-Ilan University

来源：

FEBS LETTERS | 1996年 / 394卷 / 02期

关键词：

nerve growth factor; IL-10; IFN-gamma; brain inflammation; astrocyte;

D O I：

10.1016/0014-5793(96)00911-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During the course of brain injury and inflammation there is an increased secretion of neurotrophic substances by astrocytes, We have examined the effect of the Th2-derived cytokine IL-10 and the Th1-derived cytokines IL-2 and IFN-gamma on the secretion of NGF by mouse astrocytes. IL-10 induced a dose-dependent increase in NGF secretion which was blocked by anti-IL-10 antibody, In contrast, the Th1-derived cytokines IFN-gamma and IL-2 did not induce NGF synthesis, Moreover, INF-gamma completely inhibited the increase in NGF secretion induced by IL-10 whereas it had no effect on the induction of NGF by TNF-alpha. These results indicate that IL-10 similarly to other Th2-derived cytokines may provide a neurotrophic support to injured neurons via the induction of NGF synthesis, whereas the Th1-derived cytokine IFN-gamma antagonizes this effect.

引用

页码：117 / 120

页数：4

共 38 条

[31] CYTOKINE NETWORK IN THE CENTRAL-NERVOUS-SYSTEM AND ITS ROLES IN GROWTH AND DIFFERENTIATION OF GLIAL AND NEURONAL CELLS [J].