Cytoprotective effects of AP39, a mitochondrially targeted hydrogen sulfide donor in oxidatively stressed endothelial cells: Protection against the loss of cell viability and bioenergetics and attenuation of mitochondrial DNA injury

被引：0
|
作者：
Szczesny, Bartosz [1 ]
Modis, Katalin [1 ]
Yanagi, Kazunori [1 ]
Le Trionnaire, Sophie [2 ]
Wood, Mark E. [3 ]
Whiteman, Matthew [3 ]
Szabo, Csaba [1 ]
机构：
[1] Univ Texas Med Branch, Dept Anesthesiol, Galveston, TX 77555 USA
[2] Univ Exeter, Sch Med, Exeter, Devon, England
[3] Univ Exeter, Coll Life & Environm Sci, Exeter EX4 4QJ, Devon, England
来源：
NITRIC OXIDE-BIOLOGY AND CHEMISTRY | 2014年 / 39卷
关键词：
D O I：
10.1016/j.niox.2014.03.071
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：S22 / S22
页数：1
相关论文
共 10 条
  • [1] AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro
    Szczesny, Bartosz
    Modis, Katalin
    Yanagi, Kazunori
    Coletta, Ciro
    Le Trionnaire, Sophie
    Perry, Alexis
    Wood, Mark E.
    Whiteman, Matthew
    Szabo, Csaba
    NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2014, 41 : 120 - 130
  • [2] AP39, a Mitochondrial-Targeted Hydrogen Sulfide Donor, Protects Against Mitochondrial Dysfunction in Irradiated Mouse Retinal Endothelial Cells
    Xiao, A. Y.
    Brummett, A.
    Maynard, M.
    Pidikiti, R.
    Miriyala, S.
    Panchatcharam, M.
    Sheibani, N.
    Wood, M. E.
    Whiteman, M.
    Harrison, L.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2018, 102 (03): : E170 - E170
  • [3] AP39, a mitochondrially targeted hydrogen sulfide donor, exerts protective effects in a rat model of renal ischemia-reperfusion
    Ahmad, Akbar
    Olah, Gabor
    Szczesny, Bartosz
    Wood, Mark E.
    Whiteman, Matthew
    Szabo, Csaba
    NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2015, 47 : S43 - S43
  • [4] AP39, A MITOCHONDRIALLY TARGETED HYDROGEN SULFIDE DONOR, EXERTS PROTECTIVE EFFECTS IN RENAL EPITHELIAL CELLS SUBJECTED TO OXIDATIVE STRESS IN VITRO AND IN ACUTE RENAL INJURY IN VIVO
    Ahmad, Akbar
    Olah, Gabor
    Szczesny, Bartosz
    Wood, Mark E.
    Whiteman, Matthew
    Szabo, Csaba
    SHOCK, 2016, 45 (01): : 88 - 97
  • [5] Mitochondira-targeted hydrogen sulfide donors AP39 and AP123 attenuate hyperglycaemia-induced oxidative stress and loss of bioenergetics in microvascular endothelial cells
    Gero, Domokos
    Szczesny, Bartosz
    Modis, Katalin
    Yanagi, Kazunori
    Wood, Mark E.
    Perry, Alexis
    Szabo, Csaba
    Whiteman, Matthew
    NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2014, 39 : S22 - S23
  • [6] AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer's Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons
    Zhao, Feng-li
    Fang, Fang
    Qiao, Pei-feng
    Yan, Ning
    Gao, Dan
    Yan, Yong
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2016, 2016
  • [7] The novel mitochondria-targeted hydrogen sulfide (H2S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro
    Gero, Domokos
    Torregrossa, Roberta
    Perry, Alexis
    Waters, Alicia
    Le-Trionnaire, Sophie
    Whatmore, Jacqueline L.
    Wood, Mark
    Whiteman, Matthew
    PHARMACOLOGICAL RESEARCH, 2016, 113 : 186 - 198
  • [8] Novel Mitochondria-Targeted Hydrogen Sulfide (H2S) Donors AP39 and AP123 Attenuate Hyperglycaemia-Induced Oxidative Stress and Loss of Bioenergetics in Microvascular Endothelial Cells
    Gero, Domokos
    Szczesny, Bartosz
    Perry, Alexis
    Modis, Katalin
    Wood, Mark E.
    Szabo, Csaba
    Whiteman, Matthew
    FREE RADICAL BIOLOGY AND MEDICINE, 2014, 76 : S118 - S118
  • [9] RT01, A Novel Derivative of the Mitochondria-targeted Hydrogen Sulfide Donor AP39, Reversed Hyperglycaemia-induced Mitochondrial Dysfunction in Murine Brain Microvascular Endothelial Cells
    Waters, Alicia
    Torregrossa, Roberta
    Gero, Domokos
    Perry, Alexis
    Wood, Mark E.
    Whiteman, Matthew
    FREE RADICAL BIOLOGY AND MEDICINE, 2017, 112 : 157 - 158
  • [10] Novel mitochondria-targeted hydrogen sulfide (H2S) donors stimulate cellular bioenergetics and protect endothelial cells from oxidative stress-induced injury and mitochondrial DNA damage
    Whiteman, Matt
    Szabo, Csaba
    NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2014, 42 : 142 - 142
1