Epigenetics and male reproduction: the consequences of paternal lifestyle on fertility, embryo development, and children lifetime health

被引：146
作者：
Stuppia, Liborio [1 ,3 ]
Franzago, Marica [1 ]
Ballerini, Patrizia [2 ]
Gatta, Valentina [1 ,3 ]
Antonucci, Ivana [1 ,3 ]
机构：
[1] G dAnnunzio Univ Chieti Pescara, Dept Psychol Hlth & Terr Sci, Sch Med & Hlth Sci, Lab Mol Genet, I-66013 Chieti, Italy
[2] G dAnnunzio Univ Chieti Pescara, Lab Pharmacogenet, Dept Psychol Hlth & Terr Sci, Sch Med & Hlth Sci, I-66013 Chieti, Italy
[3] Univ G DAnnunzio, CeSIMeT, I-66013 Chieti, Italy
来源：
CLINICAL EPIGENETICS | 2015年 / 7卷
关键词：
Male infertility; Gametogenesis; Epigenetics; DNA methylation; Transgenerational effect; IN-VITRO FERTILIZATION; ENDOCRINE DISRUPTOR VINCLOZOLIN; BECKWITH-WIEDEMANN-SYNDROME; CHROMOSOMAL DNA HAPLOTYPE; H19 METHYLATION IMPRINT; GERM-CELL DEVELOPMENT; ADULT-ONSET DISEASE; NON-CPG METHYLATION; SLOW GROWTH PERIOD; MALE-INFERTILITY;
D O I：
10.1186/s13148-015-0155-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The correlation between epigenetics and human reproduction represents a very interesting field of study, mainly due to the possible transgenerational effects related to epigenetic modifications of male and female gametes. In the present review, we focused our attention to the role played by epigenetics on male reproduction, evidencing at least four different levels at which sperm epigenetic modifications could affect reproduction: (1) spermatogenesis failure; (2) embryo development; (3) outcome of assisted reproduction technique (ART) protocols, mainly as concerning genomic imprinting; and (4) long-term effects during the offspring lifetime. The environmental agents responsible for epigenetic modifications are also examined, suggesting that the control of paternal lifestyle prior to conception could represent in the next future a novel hot topic in the management of human reproduction.
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页数：15
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