Concurrent parathyroid adenomas and carcinoma in the setting of multiple endocrine neoplasia type 1: Presentation as hypercalcemic crisis

被引：55

作者：

Dionisi, S

Minisola, S

Pepe, J

De Geronimo, S

Paglia, F

Memeo, L

Fitzpatrick, LA

机构：

[1] Mayo Clin, Endocrine Res Unit, Div Endocrinol Diabet Metab Nutr & Internal Med, Rochester, MN 55905 USA

[2] Univ Roma La Sapienza, Dept Surg, Rome, Italy

[3] Univ Roma La Sapienza, Dept Clin Sci, Rome, Italy

来源：

MAYO CLINIC PROCEEDINGS | 2002年 / 77卷 / 08期

关键词：

D O I：

10.4065/77.8.866

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe a patient with multiple endocrine neoplasia type 1 characterized by the simultaneous occurrence of parathyroid cancer, parathyroid adenomas, and pancreatic gastrinoma, who presented with an episode of acute hypercalcemia. The rapid parathyroid hormone assay provided a basis for the diagnosis of parathyroid hyperfunction. Mediastinal metastasis of the parathyroid carcinoma was found at autopsy. However, the staining of pancreatic and gastric tissue for parathyroid hormone-related protein does not make it possible to exclude completely the contribution of this peptide in mediating the hypercalcemia. To our knowledge, this is the first reported case of parathyroid carcinoma as part of the multiple endocrine neoplasia type 1 syndrome.

引用

页码：866 / 869

页数：4

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