The antiphospholipid antibodies

被引：0
作者：
Tanaseanu, C [1 ]
Moldoveanu, E [1 ]
St Tanaseanu [1 ]
Popescu, LM [1 ]
机构：
[1] Emergency Hosp St Pantelimon, Dept Internal Med, Bucharest, Romania
来源：
HAEMATOLOGIA | 2002年 / 31卷 / 04期
关键词：
antiphospholipid antibodies; antiphospholipid syndrome; thrombosis;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Antiphospholipid antibodies (APLAs) are a group ol autoantibodies directed against certain phospholipids, or their protein cofactors. Assay of APLAs is important because their interaction with anionic phospholipid-protein cofactors can generate a syndrome of hypercoagulability associated with a wide variety of thromboembolic events. This article presents the characteristics of some APLAs [anticardiolipin antibodies (aCLAs), lupus anticoagulant (LA) and anti-beta2-glycoprotein I antibodies (anti-beta2-GPIAs)], their action, and their interaction with blood and endothelial cells. The presence of APLAs has been reported in many diseases (autoimmune diseases, atherosclerosis, infections, malignancies), being related to pathogenic mechanisms and/or to a more severe evolution of the disease.
引用
收藏
页码：287 / 302
页数：16
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