Sensory recovery following decellularized nerve allograft transplantation for digital nerve repair

被引：40

作者：

Guo, Yang ^{[1
]}

Chen, Gary ^{[1
]}

Tian, Guanglei ^{[1
]}

Tapia, Carla ^{[1
]}

机构：

[1] Beijing Univ, Clin Hosp 4, Beijing Jishuitan Hosp, Dept Hand Surg, Beijing 100871, Peoples R China

来源：

JOURNAL OF PLASTIC SURGERY AND HAND SURGERY | 2013年 / 47卷 / 06期

关键词：

Nerve repair; allograft; nerve graft; hand trauma; RECONSTRUCTION; REGENERATION; GRAFTS; PROTEOGLYCAN; CONDUITS; INJURIES; MOTOR;

D O I：

10.3109/2000656X.2013.778862

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

This study reported preliminary clinical experience of using decelluarised nerve allograft material for repair of digital nerve defect in five hand injury patients. From October 2009 to July 2010, five patients with traumatic nerve defect were treated with nerve repair using AxoGen (R) nerve allograft (AxoGen Inc, Alachua, FL) in California Hospital Medical Center. All patients were followed at least for 12 months, and sensory recovery and signs of infection or rejection were documented by a hand therapist. Average two-point discrimination was 6 mm, and average Semmes-Weinstein Monofilaments test was 4.31. No wound infections or signs of rejections were observed at wound site. All patients reported sensory improvement during the follow-up period after operation. It is believed that decellularised nerve allografts may provide a readily available option for repair of segmental nerve defect.

引用

页码：451 / 453

页数：3

共 20 条

[1] Nerve repair by means of tubulization: Literature review and personal clinical experience comparing biological and synthetic conduits for sensory nerve repair [J].