The expression of cyclooxygenase-2 and vascular endothelial growth factor in the endometrium during the peri-implantation period in women with and without polyps

被引：4
作者：
Xiao, Y. [1 ,2 ,3 ]
Peng, X. [1 ]
Ma, N. [1 ]
Li, T. C. [2 ,3 ]
Xia, E. [1 ]
机构：
[1] Capital Med Univ, Fuxing Hosp, Hysterosop Ctr, Beijing 100038, Peoples R China
[2] Sheffield Teaching Hosp, Dept Obstet & Gynaecol, Sheffield, S Yorkshire, England
[3] Sheffield Hallam Univ, Sheffield S1 1WB, S Yorkshire, England
来源：
HUMAN FERTILITY | 2014年 / 17卷 / 01期
关键词：
Cyclooxygenase-2; vascular endothelial growth factor; endometrial polyps; infertility; ESTROGEN-RECEPTOR; ANGIOGENESIS; IMPLANTATION; COX-2;
D O I：
10.3109/14647273.2013.868933
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: This prospective study was designed to determine whether the expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in the endometrial tissue obtained from the peri-implantation period of women with endometrial polyp (EP) differs from that of control subjects without a polyp. Methods: Endometrial samples were collected from 30 patients with EP and 30 control subjects without EP, in the mid-secretory phase. The expression of COX-2 and VEGF in the endometrium was examined with the use of immunohistochemistry. Results: COX-2 and VEGF were predominantly expressed in endometrial glands. The expression of COX-2 and VEGF in the endometrium obtained from women with EP was lower than that of control subjects. Conclusion: The reduced expression of COX-2 and VEGF in the endometrium of women with EP may account for the association between EP and infertility.
引用
收藏
页码：67 / 71
页数：5
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