Re-evaluation of the outcome of a multiple component reaction -: 2-and 3-amino-imidazo[1,2-a]pyrimidines?

被引:76
作者
Mandair, GS [1 ]
Light, M [1 ]
Russell, A [1 ]
Hursthouse, M [1 ]
Bradley, M [1 ]
机构
[1] Univ Southampton, Dept Chem, Combinatorial Ctr Excellence, Southampton SO17 1BJ, Hants, England
基金
英国工程与自然科学研究理事会;
关键词
D O I
10.1016/S0040-4039(02)00709-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Multi-component reactions between aldehydes, isonitriles and 2-aminoazines do not always give the expected products. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:4267 / 4269
页数:3
相关论文
共 14 条
[1]  
Bienaymé H, 1998, ANGEW CHEM INT EDIT, V37, P2234, DOI 10.1002/(SICI)1521-3773(19980904)37:16<2234::AID-ANIE2234>3.0.CO
[2]  
2-R
[3]   Parallel synthesis of 3-aminoimidazo[1,2-a]pyridines and pyrazines by a new three-component condensation [J].
Blackburn, C ;
Guan, B ;
Fleming, P ;
Shiosaki, K ;
Tsai, S .
TETRAHEDRON LETTERS, 1998, 39 (22) :3635-3638
[4]   A three-component solid-phase synthesis of 3-aminoimidazo[1,2-a]azines [J].
Blackburn, C .
TETRAHEDRON LETTERS, 1998, 39 (31) :5469-5472
[5]   A novel dealkylation affording 3-aminoimidazo[1,2-a]pyridines:: access to new substitution patterns by solid-phase synthesis [J].
Blackburn, C ;
Guan, B .
TETRAHEDRON LETTERS, 2000, 41 (10) :1495-1500
[6]   SYNTHESIS AND ANTIBRONCHOSPASTIC ACTIVITY OF 8-ALKOXY AND 8-(ALKYLAMINO)IMIDAZO[1,2-A]PYRAZINES [J].
BONNET, PA ;
MICHEL, A ;
LAURENT, F ;
SABLAYROLLES, C ;
RECHENCQ, E ;
MANI, JC ;
BOUCARD, M ;
CHAPAT, JP .
JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (18) :3353-3358
[7]   Universal Rink-isonitrile resin:: application for the traceless synthesis of 3-acylamino imidazo[1,2-a] pyridines [J].
Chen, JJ ;
Golebiowski, A ;
McClenaghan, J ;
Klopfenstein, SR ;
West, L .
TETRAHEDRON LETTERS, 2001, 42 (12) :2269-2271
[8]   Synthesis of imidazo[1,2-a] annulated pyridines, pyrazines and pyrimidines by a novel three-component condensation [J].
Groebke, K ;
Weber, L ;
Mehlin, F .
SYNLETT, 1998, (06) :661-+
[9]   Short synthesis and anti-rhinoviral activity of imidazo[1,2-a]pyridines:: The effect of acyl groups at 3-position [J].
Hamdouchi, C ;
Ezquerra, J ;
Vega, JA ;
Vaquero, JJ ;
Alvarez-Builla, J ;
Heinz, BA .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (10) :1391-1394
[10]  
MARUYAMA Y, 1981, ARZNEIMITTEL-FORSCH, V31-2, P1111