The Regulation of Type I Interferon Production by Paramyxoviruses

被引:63
作者
Goodbourn, Stephen [2 ]
Randall, Richard E. [1 ]
机构
[1] Univ St Andrews, Sch Biol, St Andrews KY16 9ST, Fife, Scotland
[2] Univ London, Div Basic Med Sci, London, England
基金
英国惠康基金;
关键词
RESPIRATORY SYNCYTIAL VIRUS; VIRAL-RNA SYNTHESIS; NONSTRUCTURAL C PROTEIN; INDUCED ANTIVIRAL STATE; CYSTEINE-RICH DOMAIN; DOUBLE-STRANDED-RNA; MEASLES-VIRUS; V-PROTEIN; SENDAI-VIRUS; RIG-I;
D O I
10.1089/jir.2009.0071
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Experimentally, paramyxoviruses are conventionally considered good inducers of type I interferons (IFN-alpha/beta), and have been used as agents in the commercial production of human IFN-alpha. However, in the last few years it has become clear that viruses in general mount a major challenge to the IFN system, and paramyxoviruses are no exception. Indeed, most paramyxoviruses encode mechanisms to inhibit both the production of, and response to, type I IFN. Here we review our knowledge of the type I IFN-inducing signals (by so-called pathogen-associated molecular patterns, or PAMPs) produced during paramyxovirus infections, and discuss how paramyxoviruses limit the production of PAMPs and inhibit the cellular responses to PAMPs by interfering with the activities of the pattern recognition receptors (PRRs), mda-5, and RIG-I, as well as downstream components in the type I IFN induction cascades.
引用
收藏
页码:539 / 547
页数:9
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