Distribution of bemitil in organs and tissues of rats after single or repeated administration

被引：4
|
作者：
Sergeeva, S. A. [1 ]
Gulyaeva, I. L. [1 ]
机构：
[1] All Russia Res Ctr Safety Biol Active Substances, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2006年 / 141卷 / 05期
关键词：
bemitil; ethylthiobenzimidazole hydrobromide; pharmacokinetics; distribution;
D O I：
10.1007/s10517-006-0230-0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
After single and repeated peroral administration of bemitil to rats this drug was found in the liver, brain, kidneys, spleen, heart, skeletal muscles, lungs, adipose tissue, and testicles. After single treatment accumulation of bemitil was most pronounced in the liver. After repeated treatment the decrease in bemitil concentration in the liver was probably associated with increased elimination of the drug from liver tissue due to intensification of its biotransformation. We conclude that bemitil can accumulate in the blood, but not in tissues.
引用
收藏
页码：596 / 598
页数：3
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