Autophagy-independent increase of ATG5 expression in T cells of multiple sclerosis patients

被引：22

作者：

Paunovic, Verica ^{[1
]}

Petrovic, Irena Vukovic ^{[1
]}

Milenkovic, Marina ^{[1
]}

Janjetovic, Kristina ^{[1
,2
]}

Pravica, Vera ^{[1
]}

Dujmovic, Irena ^{[3
]}

Milosevic, Emina ^{[1
]}

Martinovic, Vanja ^{[3
]}

Mesaros, Sarlota ^{[3
]}

Drulovic, Jelena ^{[3
]}

Trajkovic, Vladimir ^{[1
]}

机构：

[1] Univ Belgrade, Sch Med, Inst Microbiol & Immunol, Dr Subotica 1, Belgrade 11000, Serbia

[2] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Despota Stefana Blvd 142, Belgrade 11000, Serbia

[3] Univ Belgrade, Sch Med, Clin Ctr Serbia, Clin Neurol, Dr Subotica 6, Belgrade 11000, Serbia

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2018年 / 319卷

关键词：

Multiple sclerosis; T cells; Autophagy; ATG5; LC3; SQSTM1; TNF; CANCER-CELLS; APOPTOSIS; TNF; METHYLPREDNISOLONE; INHIBITION; MACHINERY; SURVIVAL; GENES;

D O I：

10.1016/j.jneuroim.2018.03.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autophagy, a process of controlled self-digestion which regulates cell homeostasis, is involved in innate and adaptive immunity. We investigated the expression of autophagy genes and autophagic activity in distinct lymphocyte populations in treatment-naive MS patients. The mRNA and protein levels of autophagy-related (ATG)5, required for autophagosome formation, were increased in CD4(+) and CD4(-) T cells, but not B cells of MS patients compared to control subjects. The expression of other investigated autophagy genes, as well as the autophagic activity, did not significantly differ between the two groups. ATG5 mRNA levels in CD4(+) T cells from MS patients were positively correlated with those of the proinflammatory cytokine tumor necrosis factor. These data suggest that autophagy-independent increase in ATG5 expression might be associated with the proinflammatory capacity of T cells in multiple sclerosis.

引用

页码：100 / 105

页数：6

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