Genetic determinants of ammonia-induced acute lung injury in mice

被引：10

作者：

Bein, Kiflai ^{[1
]}

Ganguly, Koustav ^{[1
,2
]}

Martin, Timothy M. ^{[1
]}

Concel, Vincent J. ^{[1
]}

Brant, Kelly A. ^{[1
]}

Di, Y. P. Peter ^{[1
]}

Upadhyay, Swapna ^{[1
,2
]}

Fabisiak, James P. ^{[1
]}

Vuga, Louis J. ^{[3
,5
]}

Kaminski, Naftali ^{[3
,4
,5
]}

Kostem, Emrah ^{[6
,7
]}

Eskin, Eleazar ^{[6
,7
]}

Prows, Daniel R. ^{[8
,9
]}

Jang, Ann-Soo ^{[10
]}

Leikauf, George D. ^{[1
]}

机构：

[1] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Environm & Occupat Hlth, Pittsburgh, PA 15261 USA

[2] Karolinska Inst, Inst Environm Med, Unit Integrated Toxicol, Stockholm, Sweden

[3] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA

[4] Univ Pittsburgh, Simmons Ctr Interstitial Lung Dis, Dept Med, Pittsburgh, PA USA

[5] Yale Sch Med, Dept Med, Pulm Crit Care & Sleep Med, New Haven, CT USA

[6] Univ Calif Los Angeles, Dept Comp Sci, Los Angeles, CA 90024 USA

[7] Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA USA

[8] Univ Cincinnati, Cincinnati Childrens Hosp, Div Human Genet, Cincinnati, OH USA

[9] Univ Cincinnati, Dept Pediat, Cincinnati, OH USA

[10] Soonchunhyang Univ, Dept Internal Med, Bucheon Hosp, Div Allergy & Resp Med, Bucheon, South Korea

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | 2021年 / 320卷 / 01期

关键词：

acute lung injury; ARDS; chemical threat; functional genomics; transcriptomics; ACID PHENETHYL ESTER; HISTAMINE H-4 RECEPTOR; RESPIRATORY-DISTRESS-SYNDROME; MOUSE STRAINS; ISCHEMIA-REPERFUSION; CHEMICAL INCIDENTS; DNA-SYNTHESIS; INFLAMMATION; INHALATION; ASSOCIATION;

D O I：

10.1152/ajplung.00276.2020

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

In this study, a genetically diverse panel of 43 mouse strains was exposed to ammonia, and genome-wide association mapping was performed employing a single-nucleotide polymorphism (SNP) assembly. Transcriptomic analysis was used to help resolve the genetic determinants of ammonia-induced acute lung injury. The encoded proteins were prioritized based on molecular function, nonsynonymous SNP within a functional domain or SNP within the promoter region that altered expression. This integrative functional approach revealed 14 candidate genes that included Aatf, Avil, Cep162, Hrh4, Lama3, Plcb4, and Ube2cbp, which had significant SNP associations, and Aff1, Bcar3, Cntn4, Kcnq5, Prdm10, Ptcd3, and Snx19, which had suggestive SNP associations. Of these genes, Bcar3, Cep162, Hrh4, Kcnq5, and Lama3 are particularly noteworthy and had pathophysiological roles that could be associated with acute lung injury in several ways.

引用

页码：L41 / L62

页数：22

共 167 条

[1] Histamine receptors are hot in immunopharmacology [J].

Akdis, CA ;

Simons, FER .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2006, 533 (1-3) :69-76

[2]

Akdis Cezmi A., 2008, V94, P67, DOI 10.1159/000154858

[3] Does propofol or caffeic acid phenethyl ester prevent lung injury after hindlimb ischaemia-reperfusion in ventilated rats? [J].

Akyol, A ;

Ulusoy, H ;

Imamoglu, M ;

Çay, A ;

Yulug, E ;

Alver, A ;

Ertürk, E ;

Kosucu, M ;

Besir, A ;

Akyol, A ;

Özen, I .

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 2006, 37 (05) :380-387

[4]

Anderson AR, 2015, MMWR SURVEILL SUMM, V64, P39

[5]

[Anonymous], 1991, MERR WEBST NEW BOOK, P12

[6] Heat Shock Protein 90 Inhibitors Protect and Restore Pulmonary Endothelial Barrier Function [J].

Antonov, Alexander ;

Snead, Connie ;

Gorshkov, Boris ;

Antonova, Galina N. ;

Verin, Alexander D. ;

Catravas, John D. .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2008, 39 (05) :551-559

[7] AMMONIA INHALATION [J].

ARWOOD, R ;

HAMMOND, J ;

WARD, GG .

JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 1985, 25 (05) :444-447

[8] A Genome-Wide Association Study for Diabetic Retinopathy in a Japanese Population: Potential Association with a Long Intergenic Non-Coding RNA [J].

Awata, Takuya ;

Yamashita, Hisakuni ;

Kurihara, Susumu ;

Morita-Ohkubo, Tomoko ;

Miyashita, Yumi ;

Katayama, Shigehiro ;

Mori, Keisuke ;

Yoneya, Shin ;

Kohda, Masakazu ;

Okazaki, Yasushi ;

Maruyama, Taro ;

Shimada, Akira ;

Yasuda, Kazuki ;

Nishida, Nao ;

Tokunaga, Katsushi ;

Koike, Asako .

PLOS ONE, 2014, 9 (11)

[9] Genetic Associations With Diabetic Retinopathy and Coronary Artery Disease in Emirati Patients With Type-2 Diabetes Mellitus [J].

Azzam, Sarah K. ;

Osman, Wael M. ;

Lee, Sungmun ;

Khalaf, Kinda ;

Khandoker, Ahsan H. ;

Almahmeed, Waal ;

Jelinek, Herbert F. ;

Al Safar, Habiba S. .

FRONTIERS IN ENDOCRINOLOGY, 2019, 10

[10] Transport Mode Selection for Toxic Gases: Rail or Road? [J].

Bagheri, Morteza ;

Verma, Manish ;

Verter, Vedat .

RISK ANALYSIS, 2014, 34 (01) :168-186

← 1 2 3 4 5 6 7 8 9 10 →