Heteroaryl Ethers by Oxidative Palladium Catalysis of Pyridotriazol-1-yloxy Pyrimidines with Arylboronic Acids

被引：13

作者：

Bardhan, Sujata ^{[1
]}

Wacharasindhu, Sumrit ^{[1
]}

Wan, Zhao-Kui ^{[1
]}

Mansour, Tarek S. ^{[1
]}

机构：

[1] Wyeth Res, Chem Sci, Pearl River, NY 10965 USA

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 12期

关键词：

ARYL BORONIC ACIDS; C-O BOND; BASE-FREE; COUPLING REAGENTS; SNAR REACTIONS; AMINO-ACIDS; EFFICIENT; DERIVATIVES; HETEROCYCLES; ACTIVATION;

D O I：

10.1021/ol900592b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The oxidative palladium-catalyzed cross-coupling of pyrimidines containing pyridotriazol-1-yloxy (OPt) as either a urea or an amide functional group with arylboronic acids in the presence of CS2CO3 in DME containing 0.6-1.0% H2O is described for the preparation of heteroaryl ethers. The bromo substitution in the case of 3-(5-bromo-pyrimidin-2-yloxy)-3H-[1,2,3]triazolo[4,5-b]pyridine 1 could serve as a handle for further elaborations such as Suzuki coupling for attaching varied aryl groups.

引用

收藏

页码：2511 / 2514

页数：4

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