Optimization of antimicrobial therapy in vancomycin-resistant enterococcal bacteraemia using a rapid detection Gram-positive blood culture assay

被引：4
作者：
Nakagawa, R. [1 ,2 ]
Jain, R. [1 ,2 ,3 ]
Bryan, A. B. [4 ]
Chan, J. D. [2 ,3 ,5 ]
机构：
[1] Univ Washington, Med Ctr, Dept Pharm, Seattle, WA 98195 USA
[2] Univ Washington, Sch Pharm, Seattle, WA 98195 USA
[3] Univ Washington, Sch Med, Dept Med, Div Allergy & Infect Dis, Seattle, WA 98195 USA
[4] Univ Washington, Med Ctr, Dept Lab Med, Seattle, WA 98195 USA
[5] Harborview Med Ctr, Dept Pharm, Seattle, WA 98104 USA
来源：
JOURNAL OF HOSPITAL INFECTION | 2018年 / 99卷 / 02期
关键词：
Gram-positive blood culture assay; Vancomycin-resistant enterococcus; Bacteraemia; Antimicrobial optimization; METHICILLIN-RESISTANT; STREAM INFECTIONS; STEWARDSHIP; OUTCOMES; IMPACT;
D O I：
10.1016/j.jhin.2017.12.012
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Rapid molecular blood culture Gram-positive (BC-GP) assay can promptly identify vancomycin-resistant enterococcal (VRE) bloodstream infections (BSIs). We sought to evaluate patients with VRE BSI following the pre (N = 44) and post (N = 20) implementation of Verigene BC-GP assay. The average time to detection of VRE was 25.9 +/- 4.1 h (95% confidence interval (Cl): 17.6-34.1; P < 0.001) earlier with Verigene BC-GP assay. Compared to patients in the pre-Verigene BC-GP period, the mean adjusted difference in time to administration of anti-VRE therapy was 18.2 +/- 7.8h (95% Cl: 2.5- 33.8; P = 0.024) earlier among patients in the post-Verigene BC-GP period. Published by Elsevier Ltd on behalf of The Healthcare Infection Society.
引用
收藏
页码：153 / 157
页数：5
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