Epigenetic and microRNA-dependent control of cytochrome P450 expression: a gap between DNA and protein

被引：27
作者：
Gomez, Alvin [1 ]
Ingelman-Sundberg, Magnus [1 ]
机构：
[1] Karolinska Inst, Pharmacogenet Sect, Dept Physiol & Pharmacol, SE-17177 Stockholm, Sweden
来源：
PHARMACOGENOMICS | 2009年 / 10卷 / 07期
关键词：
cytochrome P450; DNA methylation; epigenetics histone modifications; miRNA; ISLAND METHYLATOR PHENOTYPE; TUMOR-SPECIFIC EXPRESSION; INDUCED GENE-EXPRESSION; PREGNANE X RECEPTOR; CPG-ISLANDS; MICROSATELLITE INSTABILITY; CHROMATIN MODIFICATIONS; HISTONE DEACETYLASE; COLORECTAL-CANCER; NONCODING RNAS;
D O I：
10.2217/PGS.09.56
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Although pharmacogenetics has been instrumental in describing interindividual variations in drug metabolism, epigenetic factors offer another blanket of information that could give a more vivid picture and help in developing a more personalized therapy. The dynamic aspect of epigenetics could likewise provide more definite answers to the role of changing environmental factors in drug response: the bridge that connects the environment to the genome. In this review we discuss known epigenetic and microRNA-dependent regulation of the human drug-metabolizing cytochromes P450 to help explain the unknown factors of variable drug response.
引用
收藏
页码：1067 / 1076
页数：10
相关论文
共 106 条
  • [11] CPG ISLANDS AND GENES
    CROSS, SH
    BIRD, AP
    [J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 1995, 5 (03) : 309 - 314
  • [12] Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation
    Dannenberg, Luke O.
    Edenberg, Howard J.
    [J]. BMC GENOMICS, 2006, 7 (1)
  • [13] Ligand binding and activation of the Ah receptor
    Denison, MS
    Pandini, A
    Nagy, SR
    Baldwin, EP
    Bonati, L
    [J]. CHEMICO-BIOLOGICAL INTERACTIONS, 2002, 141 (1-2) : 3 - 24
  • [14] Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53
    Denissenko, MF
    Pao, A
    Tang, MS
    Pfeifer, GP
    [J]. SCIENCE, 1996, 274 (5286) : 430 - 432
  • [15] Doerfler W, 2006, CURR TOP MICROBIOL, V301, P125
  • [16] Non-coding RNA genes and the modern RNA world
    Eddy, SR
    [J]. NATURE REVIEWS GENETICS, 2001, 2 (12) : 919 - 929
  • [17] A passion for P450s (remembrances of the early history of research on cytochrome P450)
    Estabrook, RW
    [J]. DRUG METABOLISM AND DISPOSITION, 2003, 31 (12) : 1461 - 1473
  • [18] Molecular origins of cancer: Epigenetics in cancer
    Esteller, Manel
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (11) : 1148 - 1159
  • [19] An epigenetic role for noncoding RNAs and intragenic DNA methylation
    James M Flanagan
    Laurence Wild
    [J]. Genome Biology, 8 (6)
  • [20] Epigenetic differences arise during the lifetime of monozygotic twins
    Fraga, MF
    Ballestar, E
    Paz, MF
    Ropero, S
    Setien, F
    Ballestart, ML
    Heine-Suñer, D
    Cigudosa, JC
    Urioste, M
    Benitez, J
    Boix-Chornet, M
    Sanchez-Aguilera, A
    Ling, C
    Carlsson, E
    Poulsen, P
    Vaag, A
    Stephan, Z
    Spector, TD
    Wu, YZ
    Plass, C
    Esteller, M
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (30) : 10604 - 10609
12345678910