Glutathione-dependent system of antioxidant defense in the placenta in preterm delivery

被引：12
|
作者：
Prokopenko, VM [1 ]
Partsalis, GK [1 ]
Pavlova, NG [1 ]
Burmistrov, SO [1 ]
Arutyunyan, AV [1 ]
机构：
[1] Russian Acad Med Sci, DO Ott Inst Obstet & Gynecol, St Petersburg, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2002年 / 133卷 / 05期
关键词：
glutathione peroxidase; glutathione reductase; glutathione transferase; placenta; preterm delivery;
D O I：
10.1023/A:1019845217485
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Components of the antioxidant defense system in placental tissues were studied in women with normal pregnancy and full-term delivery and women with spontaneous abortions at 2836 weeks. In women with spontaneous abortions glutathione peroxidase activity in placental tissues increased and the content of SH compounds decreased, which led to exhaustion of the antioxidant defense system. Glutathione-S-transferase activity also decreased, which attests to impaired detoxifying function of the placenta.
引用
收藏
页码：442 / 443
页数：2
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