Plasma Trimethylamine-N-oxide following Cessation of L-carnitine Supplementation in Healthy Aged Women

被引：15
作者：
Samulak, Joanna J. [1 ]
Sawicka, Angelika K. [1 ]
Samborowska, Emilia [2 ]
Olek, Robert A. [1 ]
机构：
[1] Gdansk Univ Phys Educ & Sport, Fac Rehabil & Kinesiol, Dept Bioenerget & Nutr, Gorskiego 1, PL-80336 Gdansk, Poland
[2] Polish Acad Sci, Inst Biochem & Biophys, Mass Spectrometry Lab, Pawinskiego 5a, PL-02106 Warsaw, Poland
来源：
NUTRIENTS | 2019年 / 11卷 / 06期
关键词：
cardiovascular disease; endothelial dysfunction; atherosclerosis; cholesterol; leukocytes; MICROBIOTA METABOLISM; RISK; TMAO; MEAT; PHOSPHATIDYLCHOLINE; EPIDEMIOLOGY; DISEASE;
D O I：
10.3390/nu11061322
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
L-carnitine supplementation elevates plasma trimethylamine-N-oxide (TMAO), which may participate in atherosclerosis development by affecting cholesterol metabolism. The aim of the current study was to determine the effect of increased plasma TMAO on biochemical markers in the blood following cessation of L-carnitine supplementation. The follow-up measurements were performed on subjects who completed 24 weeks of L-carnitine or placebo supplementation protocol. Blood samples were taken after finishing the supplementation and then 4 and 12 months following the supplementation withdrawal. Four months after cessation of L-carnitine supplementation, plasma TMAO concentration reached a normal level which was stable for the following eight months. During this period, no modifications in serum lipid profile and circulating leukocyte count were noted. TMAO implications in health and disease is widely discussed. The results of this study demonstrate no adverse effects of elevated plasma TMAO, induced by L-carnitine, on the measured parameters at 4 and 12 months after withdrawal of supplementation.
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页数：8
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