Selective azetidine and tetrahydropyridine formation via Pd-catalyzed cyclizations of allene-substituted amines and amino acids

被引：74
作者：
Rutjes, FPJT
Tjen, KCMF
Wolf, LB
Karstens, WFJ
Schoemaker, HE
Hiemstra, H
机构：
[1] Univ Amsterdam, Inst Mol Chem, NL-1018 WS Amsterdam, Netherlands
[2] DSM Res, Dept Organ Chem & Biotechnol, NL-6160 MD Geleen, Netherlands
来源：
ORGANIC LETTERS | 1999年 / 1卷 / 05期
关键词：
D O I：
10.1021/ol990700c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] By choosing the right substituents either highly functionalized unusual four-membered ring amino acids or the isomeric pipecolic acid derivatives are obtained in enantiomerically pure form. Starting material is a linear allene containing amino acid that has been resolved via biocatalysis.
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页码：717 / 720
页数：4
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