AIE-active theranostic system: selective staining and killing of cancer cells

被引：197
作者：
Gui, Chen [1 ,2 ]
Zhao, Engui [1 ,2 ]
Kwok, Ryan T. K. [1 ,2 ]
Leung, Anakin C. S. [1 ,2 ]
Lam, Jacky W. Y. [1 ,2 ]
Jiang, Meijuan [1 ,2 ]
Deng, Haiqin [1 ,2 ]
Cai, Yuanjing [1 ,2 ]
Zhang, Weijie [1 ,2 ]
Su, Huifang [2 ]
Tang, Ben Zhong [1 ,2 ,3 ]
机构：
[1] HKUST Shenzhen Res Inst, South Area, 9 Yuexing 1st RD,Hitech Pk Nanshan, Shenzhen 518057, Peoples R China
[2] Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Inst Adv Study Inst Mol Funct Mat, Div Biomed Engn,Dept Chem,Hong Kong Branch,State, Kowloon, Hong Kong, Peoples R China
[3] South China Univ Technol, SCUT HKUST Joint Res Lab State Key Lab Luminescen, Guangdong Innovat Res Team, Guangzhou 510640, Guangdong, Peoples R China
来源：
CHEMICAL SCIENCE | 2017年 / 8卷 / 03期
关键词：
AGGREGATION-INDUCED EMISSION; NEAR-INFRARED FLUORESCENCE; CIRCULATING TUMOR-CELLS; OPTICAL-WAVE-GUIDE; PHOTODYNAMIC THERAPY; IN-VIVO; SURGERY; PROBES; NANOPARTICLES; TECHNOLOGY;
D O I：
10.1039/c6sc04947h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cancer is the leading cause of death worldwide. With the advantages of low cost, high sensitivity and ease of accessibility, fluorescence imaging has been widely used for cancer detection in the scientific field. Aggregation-induced emission luminogens (AIEgens) are a class of synthesized fluorescent probes with high brightness and photostability in the aggregate state. Herein, a new positively-charged AIEgen, abbreviated as TPE-IQ-2O, is designed and characterized. TPE-IQ-2O not only can distinguish cancer cells from normal cells with high contrast with the aid of the difference in mitochondrial membrane potential as well as the quantity of mitochondria, but it also works as a promising photosensitizer to kill cancer cells through generation of reactive oxygen species upon white light irradiation, thus making it a promising AIE theranostic system.
引用
收藏
页码：1822 / 1830
页数：9
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